Goat Polyclonal ProSAAS antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PCSK1N aa 150-200.
Images
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PCSK1N aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UHG2
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Chimpanzee | Predicted |
| Gorilla | Predicted |
| Guinea pig | Predicted |
| Monkey | Predicted |
| Rabbit | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Guinea pig, Chimpanzee, Monkey, Gorilla | Dilution info - | Notes - |
Target data
Function
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). Big LEN. Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. PEN. Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
Alternative names
ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, pro-SAAS, Proprotein convertase 1 inhibitor, PCSK1N
Recommended products
Goat Polyclonal ProSAAS antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PCSK1N aa 150-200.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PCSK1N aa 150-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UHG2
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ProSAAS also known as PCSK1N (ProSAAS Neuropeptide) is a protein that acts as an inhibitor of prohormone convertases specifically PC1/3. It weighs approximately 28 kDa. ProSAAS expresses predominantly in neuroendocrine tissues especially in the brain and pancreatic islets. Its expression in these areas implies a significant role in neuroendocrine signaling.
- Biological function summary
ProSAAS functions as a neuropeptide precursor influencing the maturation of other peptide hormones. It is not typically considered part of a larger protein complex but interacts with other proteins to modulate their activity. ProSAAS directly inhibits catalytic activity of PC1/3 affecting the processing and sorting of various peptide hormones and neuropeptides critical for proper brain and endocrine system function.
- Pathways
Interactions between ProSAAS and its influence in the prohormone processing pathway are significant. It contributes to the regulation of the neuroendocrine signaling pathway. ProSAAS shares a regulatory network with other proteins like prohormone convertase 2 (PC2) emphasizing its role in the complex hormone maturation landscape.
- Associated diseases and disorders
Alteration in ProSAAS expression or function links to metabolic syndromes and neurodegenerative diseases. For metabolic syndromes changes in ProSAAS can impact insulin regulation linking it to diabetes via its interaction with proteins like insulin. In neurodegenerative diseases such as Alzheimer's ProSAAS appears to modulate amyloid-beta peptide formation influencing disease progression in a manner shared with amyloid precursor protein (APP).
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ProSAAS antibody (ab191283)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labeling ProSAAS with ab191283 at 5 μg/ml.
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