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AB191283

Anti-ProSAAS antibody

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(1 Publication)

Goat Polyclonal ProSAAS antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PCSK1N aa 150-200.

View Alternative Names

ProSAAS, Proprotein convertase subtilisin/kexin type 1 inhibitor, pro-SAAS, Proprotein convertase 1 inhibitor, PCSK1N

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ProSAAS antibody (AB191283)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ProSAAS antibody (AB191283)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human pancreas tissue labeling ProSAAS with ab191283 at 5 μg/ml.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PCSK1N aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q9UHG2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ProSAAS also known as PCSK1N (ProSAAS Neuropeptide) is a protein that acts as an inhibitor of prohormone convertases specifically PC1/3. It weighs approximately 28 kDa. ProSAAS expresses predominantly in neuroendocrine tissues especially in the brain and pancreatic islets. Its expression in these areas implies a significant role in neuroendocrine signaling.
Biological function summary

ProSAAS functions as a neuropeptide precursor influencing the maturation of other peptide hormones. It is not typically considered part of a larger protein complex but interacts with other proteins to modulate their activity. ProSAAS directly inhibits catalytic activity of PC1/3 affecting the processing and sorting of various peptide hormones and neuropeptides critical for proper brain and endocrine system function.

Pathways

Interactions between ProSAAS and its influence in the prohormone processing pathway are significant. It contributes to the regulation of the neuroendocrine signaling pathway. ProSAAS shares a regulatory network with other proteins like prohormone convertase 2 (PC2) emphasizing its role in the complex hormone maturation landscape.

Alteration in ProSAAS expression or function links to metabolic syndromes and neurodegenerative diseases. For metabolic syndromes changes in ProSAAS can impact insulin regulation linking it to diabetes via its interaction with proteins like insulin. In neurodegenerative diseases such as Alzheimer's ProSAAS appears to modulate amyloid-beta peptide formation influencing disease progression in a manner shared with amyloid precursor protein (APP).
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity).. Big LEN. Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.. PEN. Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding.
See full target information PCSK1N
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecules (Basel, Switzerland) 27: PubMed35268795

2022

Improved Wound Healing by Naringin Associated with MMP and the VEGF Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Hau Yen,Wan-Ting Chio,Chia-Ju Chuang,Hsin-Ling Yang,Sheng-Teng Huang
View all publications
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