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Rabbit Polyclonal PROSC antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus.

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Images

Western blot - Anti-PROSC antibody (AB151332), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (AB151332), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (AB151332), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O94903

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Expected
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Expected
Expected

Species

Mouse

Dilution info

Use at an assay dependent concentration.

Notes

-

Tested
Tested

Species

Mouse

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Target data

Function

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

Alternative names

Recommended products

Rabbit Polyclonal PROSC antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O94903
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The PROSC protein also known as proline synthetase co-transcribed homolog weighs approximately 29 kDa. Scientists find it expressed in many tissues including the liver and kidneys. Mechanically PROSC associates with the intracellular stability and transport of pyridoxal 5’-phosphate (PLP) an active form of vitamin B6. The protein influences cellular homeostasis significantly by maintaining PLP concentrations which are important for enzyme reactions in the body.

Biological function summary

PROSC maintains PLP dependency for proper enzymatic functions within cells. It does not operate as part of a larger protein complex but distinguishes itself by binding to PLP. This binding stabilizes PLP ensuring that it remains available for various biochemical processes. The action of PROSC is essential for any PLP-dependent enzymes which need the co-factor to function properly further supporting amino acid metabolism and neurotransmitter synthesis.

Pathways

Amino acid metabolism integrates PROSC into critical biological networks. It associates specifically with the vitamin B6 metabolism pathway where its role stabilizes PLP availability. Other enzymes linked with PROSC include the pyridoxal kinase which also participates in vitamin B6 metabolism. This coupling ensures that enzymes needing PLP can proceed with functional biochemical reactions throughout different cell processes.

Associated diseases and disorders

Researchers have linked PROSC with conditions like neurological deficits and epilepsy. Its interaction with proteins like pyridoxine 5'-phosphate oxidase ties it to these issues. This relationship stems from the necessity of PLP in neurotransmitter function. Disruptions in PROSC function can lead to insufficient PLP levels which then impacts proper brain function and development linking it to such neurological disorders.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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3 product images

  • Western blot - Anti-PROSC antibody (ab151332), expandable thumbnail

    Western blot - Anti-PROSC antibody (ab151332)

    12% SDS PAGE

    All lanes: Western blot - Anti-PROSC antibody (ab151332) at 1/1000 dilution

    All lanes: THP-1 whole cell lysate at 30 µg

    Predicted band size: 30 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (ab151332), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (ab151332)

    Immunohistochemical analysis of paraffin-embedded Human U87 xenograft labeling PROSC with ab151332 at 1/500 dilution.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (ab151332), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROSC antibody (ab151332)

    Immunohistochemical analysis of paraffin-embedded Mouse Muscle tissue labeling PROSC with ab151332 at 1/500 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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