Rabbit Polyclonal PROSC antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Mouse | Expected | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.
PROSC, PLPBP, PROSC, Pyridoxal phosphate homeostasis protein, PLP homeostasis protein, Proline synthase co-transcribed bacterial homolog protein, Pyridoxal phosphate-binding protein
Rabbit Polyclonal PROSC antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLPBP aa 1 to C-terminus.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The PROSC protein also known as proline synthetase co-transcribed homolog weighs approximately 29 kDa. Scientists find it expressed in many tissues including the liver and kidneys. Mechanically PROSC associates with the intracellular stability and transport of pyridoxal 5’-phosphate (PLP) an active form of vitamin B6. The protein influences cellular homeostasis significantly by maintaining PLP concentrations which are important for enzyme reactions in the body.
PROSC maintains PLP dependency for proper enzymatic functions within cells. It does not operate as part of a larger protein complex but distinguishes itself by binding to PLP. This binding stabilizes PLP ensuring that it remains available for various biochemical processes. The action of PROSC is essential for any PLP-dependent enzymes which need the co-factor to function properly further supporting amino acid metabolism and neurotransmitter synthesis.
Amino acid metabolism integrates PROSC into critical biological networks. It associates specifically with the vitamin B6 metabolism pathway where its role stabilizes PLP availability. Other enzymes linked with PROSC include the pyridoxal kinase which also participates in vitamin B6 metabolism. This coupling ensures that enzymes needing PLP can proceed with functional biochemical reactions throughout different cell processes.
Researchers have linked PROSC with conditions like neurological deficits and epilepsy. Its interaction with proteins like pyridoxine 5'-phosphate oxidase ties it to these issues. This relationship stems from the necessity of PLP in neurotransmitter function. Disruptions in PROSC function can lead to insufficient PLP levels which then impacts proper brain function and development linking it to such neurological disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
12% SDS PAGE
All lanes: Western blot - Anti-PROSC antibody (ab151332) at 1/1000 dilution
All lanes: THP-1 whole cell lysate at 30 µg
Predicted band size: 30 kDa
Immunohistochemical analysis of paraffin-embedded Human U87 xenograft labeling PROSC with ab151332 at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded Mouse Muscle tissue labeling PROSC with ab151332 at 1/500 dilution.
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