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AB192360

Anti-Prostaglandin D Synthase (hematopoietic) antibody

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(1 Publication)

Rabbit Polyclonal Prostaglandin D Synthase (hematopoietic) antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HPGDS.

View Alternative Names

GSTS, PGDS, PTGDS2, HPGDS, Hematopoietic prostaglandin D synthase, H-PGDS, GST class-sigma, Glutathione S-transferase, Glutathione-dependent PGD synthase, Glutathione-requiring prostaglandin D synthase, Prostaglandin-H2 D-isomerase

1 Images
Western blot - Anti-Prostaglandin D Synthase (hematopoietic) antibody (AB192360)
  • WB

Supplier Data

Western blot - Anti-Prostaglandin D Synthase (hematopoietic) antibody (AB192360)

All lanes:

Western blot - Anti-Prostaglandin D Synthase (hematopoietic) antibody (ab192360)

Lane 1:

THP1 whole cell lysate

Lane 2:

RAW 264.7 whole cell lysate

Lane 3:

PC12 whole cell lysate

Predicted band size: 23 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human HPGDS. The exact immunogen used to generate this antibody is proprietary information.

O60760

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Complementary Products

Primary Antibodies

AB182141

Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody [EP12357]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody [EP12357] (AB182141)

  • 3
  • 1
Primary Antibodies

AB191527

Anti-RAC2 antibody

Western blot - Anti-RAC2 antibody (AB191527)

  • 0
  • 0
Primary Antibodies

AB155005

Anti-UGDH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UGDH antibody (AB155005)

  • 0
  • 0
Primary Antibodies

AB191536

Anti-PAG608 antibody

Western blot - Anti-PAG608 antibody (AB191536)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab192360 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prostaglandin D Synthase also known as hematopoietic prostaglandin D synthase (HPGDS) is an enzyme with a mass of approximately 26 kDa. This enzyme catalyzes the conversion of prostaglandin H2 to prostaglandin D2. It is highly expressed in hematopoietic tissues like spleen and bone marrow and also in mast cells. Besides its presence in those tissues this enzyme is also found in the brain exhibiting cerebral localization in the leptomeninges and choroid plexus.
Biological function summary

Prostaglandin D synthase functions as part of the prostaglandin synthesis pathway which plays a significant role in the regulation of sleep inflammation and fever. It acts independently rather than being part of a larger protein complex. The enzyme's activity modulates the levels of prostaglandin D2 a lipid compound involved in various physiological processes such as smooth muscle contraction and inhibition of platelet aggregation.

Pathways

This enzyme holds an important position in the arachidonic acid metabolism and inflammatory response pathways. It produces prostaglandin D2 which acts as an autocrine and paracrine mediator. The pathway involves enzymes like cyclooxygenase (COX-1 and COX-2) which are involved upstream of prostaglandin D synthase in the synthesis of prostaglandin H2. This connection places prostaglandin D synthase as a downstream target for regulatory mechanisms involving cyclooxygenase enzymes.

Prostaglandin D synthase is associated with disorders related to inflammation such as asthma and rheumatoid arthritis. Prostaglandin D2 produced by this enzyme plays a role in allergic reactions and inflammation leading to conditions like asthma. In rheumatoid arthritis the enzyme's product mediates inflammatory responses in joints. Other proteins such as COX enzymes mentioned earlier are involved in these disease mechanisms with COX inhibitors often used as treatment to alleviate symptoms by reducing prostaglandin synthesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
See full target information HPGDS
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0332988 PubMed41004487

2025

Multi-omics analysis of parthanatos related molecular subgroup and prognostic model development in stomach adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangxin Wu,Lianming Cai,Yanping Liu,Bowen Wang,Tianyi Xia,Zhenhua Liu
View all publications
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