AB182784

Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody

Name: Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody (ab182784) | Abcam
Brand: Abcam Limited
SKU: AB182784

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(3 Publications)

Rabbit Polyclonal Prostaglandin D Synthase (Lipocalin)/PDS antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTGDS.

View Alternative Names

PDS, PTGDS, Prostaglandin-H2 D-isomerase, Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, L-PGDS, PGD2 synthase, PGDS, PGDS2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody (AB182784)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody (AB182784)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Prostaglandin D Synthase (Lipocalin)/PDS with ab182784 at 1/15 dilution. The image on the right was treated with the immunogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB, ELISA

applications

Immunogen

Recombinant Fragment Protein within Human PTGDS. The exact immunogen used to generate this antibody is proprietary information.

P41222

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prostaglandin D Synthase (Lipocalin) also known as PGDS or PDS is an enzyme that catalyzes the conversion of prostaglandin H2 to prostaglandin D2. It plays an important mechanical role in prostaglandin metabolism and has a mass of approximately 20 kDa. This protein is prominently expressed in the central nervous system heart and male genital organs. Its alternate name is lipocalin-type prostaglandin D synthase highlighting its membership in the lipocalin family. Notably it is abundant in cerebrospinal fluid and seminal plasma.

Biological function summary

This protein PDS participates in various physiological processes including inflammation and sleep regulation. It operates independently and is not typically part of larger protein complexes. PGDS contributes to the homeostasis of biological membranes and acts as a neuromodulator in the brain. Its function extends to mediating the actions of the prostaglandin D2 it produces affecting processes like allergic reactions and maintaining normal reproductive physiological functions.

Pathways

PGDS engages with key biological processes by being part of the MAPK signaling pathway and the arachidonic acid cascade. These pathways contribute to inflammation and immune response regulation. PGDS interacts specifically with other proteins along these pathways such as cyclooxygenases (COX-1 COX-2) which are important in the initial creation of prostaglandin H2. Its role in signaling elucidates its involvement in both central and peripheral biological activities.

PGDS links to conditions such as sleep disorders and allergic diseases. The production of prostaglandin D2 by PGDS can exacerbate symptoms of certain allergic responses including asthma. Furthermore PGDS involvement in sleep regulation can relate to narcolepsy. In these conditions it interacts with other proteins involved in prostaglandin signaling such as COX enzymes which are targeted by certain therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed : 20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed : 20667974, PubMed : 9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).

See full target information PTGDS

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in aging neuroscience 15:1282855 PubMed38035268

2023

Protection against Aβ-induced neuronal damage by KU-32: PDHK1 inhibition as important target.

Applications

Unspecified application

Species

Unspecified reactive species

Ranu Pal,Dongwei Hui,Heather Menchen,Huiping Zhao,Olivier Mozziconacci,Heather Wilkins,Brian S J Blagg,Christian Schöneich,Russell H Swerdlow,Mary L Michaelis,Elias K Michaelis

Cell reports 33:108348 PubMed33147469

2020

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Chandramohan Chitraju,Alexander W Fischer,Robert V Farese,Tobias C Walther

International journal of cancer 137:1235-44 PubMed25516376

2015

Prostaglandin D synthase is a potential novel therapeutic agent for the treatment of gastric carcinomas expressing PPARγ.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsunari Fukuoka,Masakazu Yashiro,Haruhito Kinoshita,Tamami Morisaki,Tsuyoshi Hasegawa,Toshiki Hirakawa,Naoki Aomatsu,Hiroshi Takeda,Takayuki Maruyama,Kosei Hirakawa

View all publications

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Product promise

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Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody (AB182784)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise