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Rabbit Polyclonal Prostaglandin F2 alpha Receptor/PTGFR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Prostaglandin F2-alpha receptor.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin F2 alpha Receptor/PTGFR antibody (AB188935), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human Prostaglandin F2-alpha receptor. The exact immunogen used to generate this antibody is proprietary information. Database link P43088

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Chicken
Predicted
Cow
Predicted
Dog
Predicted
Gorilla
Predicted
Horse
Predicted
Monkey
Predicted
Pig
Predicted
Rabbit
Predicted
Sheep
Predicted
Turkey
Predicted

Tested
Tested

Species
Human
Dilution info
7.00000-11.00000 µg/mL
Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species
Sheep, Rabbit, Horse, Chicken, Cow, Dog, Turkey, Pig, Monkey, Gorilla, Mouse
Dilution info
-
Notes

-

Associated Products

Select an associated product type

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Target data

Function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Alternative names

Recommended products

Rabbit Polyclonal Prostaglandin F2 alpha Receptor/PTGFR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Prostaglandin F2-alpha receptor.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human Prostaglandin F2-alpha receptor. The exact immunogen used to generate this antibody is proprietary information. Database link P43088
Purification technique
Affinity purification Immunogen
Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Prostaglandin F2 alpha Receptor also known as PTGFR is a G-protein-coupled receptor with a molecular mass of about 66 kDa. This receptor plays an essential role in mediating the effects of prostaglandin F2 alpha (PGF2α) a lipid compound involved in various physiological processes. The receptor is mainly expressed in tissues such as the uterus eye and vascular smooth muscle. Its localization allows it to actively participate in reproductive functions and other biological activities in these tissues.

Biological function summary

Prostaglandin F2 alpha Receptor functions as part of the prostanoid receptor family which mediates diverse physiological responses. PGF2α binding to the PTGFR induces intracellular signaling cascades that lead to smooth muscle contraction and modulation of inflammation. The receptor is not known to be part of any higher-order complex but interacts with intracellular signaling molecules to exert its effects. Its activity is important in processes such as luteolysis and modulation of intraocular pressure.

Pathways

The Prostaglandin F2 alpha Receptor is involved in key regulatory pathways like the prostaglandin signaling pathway and the smooth muscle contraction pathway. Within the prostaglandin signaling pathway PTGFR works with proteins such as phospholipase C to increase intracellular calcium levels leading to smooth muscle contraction. Its role in these pathways highlights its function in reproductive cycles and maintenance of cardiovascular health.

Associated diseases and disorders

The Prostaglandin F2 alpha Receptor has associations with conditions such as glaucoma and dysmenorrhea. In glaucoma the receptor's role in modulating intraocular pressure links it to elevated pressure and optic nerve damage. Similarly dysmenorrhea involves excessive uterine muscle contractions where PTGFR-mediated signaling becomes heightened. The receptor's interaction with other proteins like cyclooxygenase-2 (COX-2) exacerbates these conditions by influencing prostaglandin production and signaling.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin F2 alpha Receptor/PTGFR antibody (ab188935), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin F2 alpha Receptor/PTGFR antibody (ab188935)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human ovary tissue labeling Prostaglandin F2 alpha Receptor/PTGFR with ab188935 at 11 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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