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AB230024

Anti-Proteasome 20S beta 3 antibody

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(2 Publications)

Rabbit Polyclonal Proteasome 20S beta 3 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PSMB3.

View Alternative Names

Proteasome subunit beta type-3, Proteasome chain 13, Proteasome component C10-II, Proteasome subunit beta-3, Proteasome theta chain, beta-3, PSMB3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome 20S beta 3 antibody (AB230024)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome 20S beta 3 antibody (AB230024)

Paraffin-embedded human skin tissue stained for Proteasome 20S beta 3 with ab230024 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome 20S beta 3 antibody (AB230024)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome 20S beta 3 antibody (AB230024)

Paraffin-embedded human placenta tissue stained for Proteasome 20S beta 3 with ab230024 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PSMB3.

P49720

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Complementary Products

Proteins & Peptides

AB117227

Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Proteasome 20S beta 3 protein (His tag N-Terminus) (AB117227)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Oncorhynchus mykiss": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Proteasome 20S beta 3 also known as PSMB3 is a structural component of the proteasome complex a multicatalytic proteinase complex with a role in degradation of ubiquitinated proteins. It has a molecular mass of approximately 25 kDa. The 20S proteasome functions in the cytoplasm and nucleus expressed in all eukaryotic cells. It participates in protein homeostasis by breaking down short-lived and damaged proteins into peptides important for cellular regulation.
Biological function summary

Proteasome 20S beta 3 contributes to the assembly and function of the 26S proteasome complex. This complex facilitates the regulated degradation of intracellular proteins a process critical for various cellular processes including the cell cycle apoptosis and DNA repair. Proteasome 20S beta 3 is one of the 14 different subunits that make up the beta rings of the 20S core particle engaging in precise proteolytic activity within cells.

Pathways

Proteasome 20S beta 3 is essential in the ubiquitin-proteasome pathway a major pathway for protein catabolism. This pathway maintains protein equilibrium and modulates proteins involved in immune response and signal transduction. It closely interacts with ubiquitin ligases which tag proteins for degradation and connects to key pathways like the NF-kB signaling pathway where it can influence inflammatory responses due to its role in processing specific intracellular proteins.

Proteasome 20S beta 3's dysregulation links to cancer and neurodegenerative diseases due to its role in protein degradation. In cancer altered proteasome function can result in the accumulation of oncoproteins or degradation of tumor suppressor proteins. Also disrupted protein homeostasis contributes to neurodegenerative disorders such as Alzheimer's disease where pathogenesis often involves proteasome impairment. Its interactions with proteins like the tumor suppressor p53 highlight its significance in maintaining cellular health and prevent disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
See full target information PSMB3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 29:127 PubMed37710176

2023

Quercetin inhibits the metabolism of arachidonic acid by inhibiting the activity of CYP3A4, thereby inhibiting the progression of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Huaming Tang,Yuanli Kuang,Wan Wu,Bing Peng,Qianmei Fu

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang
View all publications
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Product promise

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