Anti-Proteasome 26S S3/PSMD3 antibody
5
(2 Reviews)
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(1 Publication)
Rabbit Polyclonal Proteasome 26S S3/PSMD3 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PSMD3 aa 1-50.
View Alternative Names
26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit RPN3, 26S proteasome regulatory subunit S3, Proteasome subunit p58, PSMD3
- IP
Unknown
Immunoprecipitation - Anti-Proteasome 26S S3/PSMD3 antibody (AB140440)
Detection of Proteasome 26S S3/PSMD3 in Immunoprecipitates of 293T whole cell lysates (1 mg for IP, 20% of IP loaded) using ab140428 at 6 μg/mg lysate for IP and 0.4μg/ml for WB detection (Lane 1). Lane 2 represents control IgG IP. Detection : Chemiluminescence with an exposure time of 10 seconds.
All lanes:
Immunoprecipitation - Anti-Proteasome 26S S3/PSMD3 antibody (ab140440)
Predicted band size: 61 kDa
false
- WB
Unknown
Western blot - Anti-Proteasome 26S S3/PSMD3 antibody (AB140440)
All lanes:
Western blot - Anti-Proteasome 26S S3/PSMD3 antibody (ab140440) at 0.1 µg/mL
Lane 1:
293T whole cell lysate at 50 µg
Lane 2:
293T whole cell lysate at 15 µg
Lane 3:
HeLa whole cell lysate at 50 µg
Lane 4:
Jurkat whole cell lysate at 50 µg
Lane 5:
NIH3T3 whole cell lysate at 50 µg
Predicted band size: 61 kDa
true
Exposure time: 30s
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteasome 26S S3 forms an integral part of the 26S proteasome a large complex involved in the ATP-dependent breakdown of proteins. This complex is essential for many cellular functions including cell cycle progression signal transduction and stress responses. By facilitating protein degradation Proteasome 26S S3 helps regulate the quantity and quality of proteins within the cell. It interacts with other proteasomal components to mediate the recognition and unfolding of target proteins enabling their subsequent degradation into smaller peptides.
Pathways
The Proteasome 26S S3 participates in the ubiquitin-proteasome pathway and the NF-κB signaling pathway. These pathways are pivotal in controlling protein turnover and are involved in cellular responses to various stimuli. Within the ubiquitin-proteasome pathway PSMD3 collaborates with other proteasome components to execute protein degradation processes. In the NF-κB pathway PSMD3 influences the degradation of IκB proteins allowing the activation of NF-κB transcription factors which regulate immune and inflammatory responses.
Product protocols
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Target data
Publications (1)
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Journal of veterinary science 21:e43 PubMed32476317
2020
Applications
Unspecified application
Species
Unspecified reactive species
Alternative Products
Complementary Products
Primary Antibodies
AB166628
Anti-Proteasome subunit beta type 2/PSMB2 antibody [EPR8826(2)(B)]
RabMAb|Recombinant
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Proteasome subunit beta type 2/PSMB2 antibody [EPR8826(2)(B)] (AB166628)](https://content.abcam.com/products/images/proteasome-subunit-beta-type-2-psmb2-antibody-epr88262b-ab166628--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img117371.jpg)
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Product promise
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