Anti-Proteasome subunit beta type-7 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Proteasome subunit beta type-7 also known as PSB7 or PSMB7 is an essential component of the 20S core proteasome complex. It has a molecular weight of approximately 27 kDa. This protein is expressed ubiquitously in human tissues indicating its broad role in cellular functions. As a catalytic subunit PSB7 contributes to the proteolytic core of the proteasome which is responsible for degrading ubiquitinated proteins through ATP-dependent proteolysis.

Biological function summary

PSB7 forms part of the larger 26S proteasome complex that plays a significant role in maintaining cellular protein homeostasis. The complex is vital for degrading misfolded damaged or short-lived regulatory proteins. The degradation process by the proteasome prevents the accumulation of defective proteins which can be harmful. PSB7 along with other beta subunits contributes to the protease activity within the central chamber of the proteasome ensuring proper peptide cleavage.

Pathways

PSB7's involvement is key to the ubiquitin-proteasome pathway an essential cellular process for protein turnover. This pathway regulates various cellular processes including cell cycle apoptosis and responses to oxidative stress. PSB7 through the proteasome interacts with proteins like ubiquitin ligases and deubiquitinating enzymes which attach or remove ubiquitin tags from substrate proteins. Additionally PSB7 is linked to the NF-kB signaling pathway where it participates in the degradation of inhibitors that regulate NF-kB activity.

Associated diseases and disorders

PSB7 plays a significant role in multiple myeloma and various types of cancer. Dysregulation of the proteasome activity with changed expression or function of PSB7 can lead to uncontrolled cell proliferation and tumor development. It also finds relevance in neurodegenerative diseases such as Alzheimer's disease where proteasome dysfunction can cause improper protein clearance and aggregation. In these diseases proteins like tau in Alzheimer's are substrates for the proteasome degradation pathway involving PSB7.