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AB26997

Anti-Protein Tax-1 antibody [1A3]

5

(2 Reviews)

|

(8 Publications)

Mouse Monoclonal TAX antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human T-cell leukemia virus type I samples. Cited in 8 publications.

View Alternative Names

HTLV1 Tax, HTLV1 p40

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1A3

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Human T-cell leukemia virus type I

Applications

ICC/IF, WB, IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human T-cell leukemia virus type I": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/50 - 1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/50 - 1/800", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/50 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein Tax-1 also known as Human T-cell Leukemia Virus Type I (HTLV-1) Tax protein is a regulatory protein with significant molecular mechanics. This protein has a molecular mass of approximately 40 kDa. It is primarily expressed in human T-cells infected with HTLV-1. Protein Tax-1 plays an important role in regulating the transcription of viral and cellular genes acting as a potent transactivator. Its expression occurs predominantly in the nucleus of HTLV-1 infected cells where it initiates the transcription of viral genes necessary for replication.
Biological function summary

Protein Tax-1 acts as a multifunctional protein involved in numerous cellular processes. It forms part of transcriptional complexes that modulate the activities of several cellular signaling pathways. These complexes comprised of Tax-1 and various host cell proteins help the virus escape immune surveillance while promoting proliferation of infected cells. Protein Tax-1's interaction with NF-kB and its ability to activate this transcription factor is central to its biological function leading to increased expression of genes involved in cell survival and proliferation.

Pathways

Protein Tax-1 significantly alters key signaling cascades within the cell. It prominently impacts the NF-kB and mitogen-activated protein kinase (MAPK) pathways. By interacting with cellular proteins like PI3K and IKK Tax-1 enhances cellular responses to mitogenic signals contributing to cell transformation and survival. The integration of Tax-1 into these pathways results in persistent activation of survival mechanisms which is pivotal in the progression of cellular abnormalities associated with viral infection.

Protein Tax-1 is tightly linked to various pathologies notably adult T-cell leukemia/lymphoma (ATLL). HTLV-1 infection and subsequent expression of the Tax-1 protein facilitate the clonal proliferation of T-cells resulting in oncogenesis. Besides ATLL Protein Tax-1 associates with the development of HTLV-1-associated myelopathy (HAM/TSP) a neurodegenerative disorder. The dysregulation of NF-kB pathways by Tax-1 and its interaction with cellular proteins such as CREB drive the inflammatory response observed in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Protein Tax-1
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8470 PubMed41006234

2025

High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques.

Applications

Unspecified application

Species

Unspecified reactive species

Sarkis Sarkis,Anna Gutowska,Mohammad Arif Rahman,Luca Schifanella,Katherine C Goldfarbmuren,Massimiliano Bissa,Ramona Moles,Christina Ramirez,Elijah F Edmondson,Andrew Warner,Melvin Doster,Isabela Silva de Castro,Robyn Washington-Parks,Sophia Brown,Joshua Kramer,Matthew W Breed,Kristin E Killoran,Yogita Jethmalani,Leonid Serebryannyy,Damian Fj Purcell,Cynthia A Pise-Masison,Genoveffa Franchini

Blood cancer journal 13:67 PubMed37137914

2023

Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival.

Applications

Unspecified application

Species

Unspecified reactive species

Rita Hleihel,Hala Skayneh,Hugues de Thé,Olivier Hermine,Ali Bazarbachi

Journal of virology 96:e0087622 PubMed36354340

2022

Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4 T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa V Fernandez-de Céspedes,Huxley K Hoffman,Hannah Carter,Lacy M Simons,Lwar Naing,Sherimay D Ablan,David A Scheiblin,Judd F Hultquist,Schuyler B van Engelenburg,Eric O Freed

Journal of virology 94: PubMed32938764

2020

Elucidating the Basis for Permissivity of the MT-4 T-Cell Line to Replication of an HIV-1 Mutant Lacking the gp41 Cytoplasmic Tail.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa V Fernandez,Huxley K Hoffman,Nairi Pezeshkian,Philip R Tedbury,Schuyler B van Engelenburg,Eric O Freed

Journal of virology 93: PubMed31554688

2019

Authentication Analysis of MT-4 Cells Distributed by the National Institutes of Health AIDS Reagent Program.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa V Fernandez,Krista A Delviks-Frankenberry,David A Scheiblin,Christine Happel,Vinay K Pathak,Eric O Freed

Biochemical and biophysical research communication 512:598-603 PubMed30914196

2019

Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenzhao Cheng,Tingjin Zheng,Yong Wang,Kun Cai,Wencai Wu,Tiejun Zhao,Ruian Xu

Leukemia research 35:1491-7 PubMed21802726

2011

Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma.

Applications

WB

Species

Unspecified reactive species

Bevin Zimmerman,Aaron Sargeant,Kristina Landes,Soledad A Fernandez,Ching-Shih Chen,Michael D Lairmore

AIDS research and human retroviruses 26:593-603 PubMed20438380

2010

Cytokine and growth factor expression by HTLV-1 Lck-tax transgenic cells in SCID mice.

Applications

WB

Species

Unspecified reactive species

Karen M Watters,Jonathan Dean,Hideki Hasegawa,Hirofumi Sawa,William Hall,Noreen Sheehy
View all publications
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Product promise

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