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AB254934

Anti-Protein Z antibody

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(1 Publication)

Rabbit Polyclonal Protein Z antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PROZ aa 250-400.

View Alternative Names

Vitamin K-dependent protein Z, PROZ

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein Z antibody (AB254934)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein Z antibody (AB254934)

Paraffin-embedded human liver tissue stained for Protein Z using ab254934 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein Z antibody (AB254934)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Protein Z antibody (AB254934)

Paraffin-embedded human pancreas tissue stained for Protein Z using ab254934 at 1/50 dilution in immunohistochemical analysis. Low expression as expected.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PROZ aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

P22891

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Complementary Products

Assay Kits

AB137989

Human Protein Z ELISA Kit

ELISA - Human Protein Z ELISA Kit (AB137989)

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Primary Antibodies

AB196023

Anti-Factor X antibody [EPR16249]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor X antibody [EPR16249] (AB196023)

  • 0
  • 0
Assay Kits

AB137989

Human Protein Z ELISA Kit

ELISA - Human Protein Z ELISA Kit (AB137989)

  • 0
  • 0
Primary Antibodies

AB242123

Anti-Factor XII antibody [EPR22292-127]

20ul selling size|RabMAb|Recombinant|Trial Size

Immunoprecipitation - Anti-Factor XII antibody [EPR22292-127] (AB242123)

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Primary Antibodies

AB248949

Anti-Protein C antibody [EPSISR8] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Protein C antibody [EPSISR8] - BSA and Azide free (AB248949)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein Z also known as PZ is a vitamin K-dependent plasma protein with a molecular mass of approximately 62 kDa. It is primarily expressed in the liver and circulates in the blood. This protein plays a mechanical role in the coagulation system by interacting with the protein Z-dependent protease inhibitor which downregulates blood coagulation contributing to hemostasis. Protein Z is different from other coagulation proteins due to its lack of enzymatic activity but impacts the regulation of thrombin formation.
Biological function summary

Protein Z serves as a significant factor in the coagulation cascade being a part of the protein C pathway complex. Although it lacks enzymatic action Protein Z interacts with other proteins such as Factor Xa and Protein Z-dependent protease inhibitor to exert its effects. Its involvement helps modulate clot formation and stabilize the coagulation process impacting blood flow regulation.

Pathways

Protein Z is intricately linked to the coagulation and thrombosis pathways. It associates with proteins including Factor Xa and Protein C. Protein Z assists in regulating thrombin generation by inhibiting excess coagulation maintaining a balance within the hemostatic system. This interaction ensures the rapid and effective stopping of blood flow when required while preventing unwarranted thrombosis a critical aspect of circulatory system maintenance.

Protein Z levels link to thrombosis and hemorrhagic disorders. Abnormalities in Protein Z levels have connections with deep vein thrombosis due to its role in regulating coagulation balance. The protein Z-dependent protease inhibitor's association highlights its significance in clot formation and thrombosis prevention. Additionally deficiencies in Protein Z have connections with bleeding disorders emphasizing the protein's role in maintaining a balanced coagulation process essential for preventing excessive bleeding or clotting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
See full target information PROZ
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS genetics 19:e1010797 PubMed37307272

2023

Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara De Luca,Anuj Gupta,Alex Bortvin
View all publications
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Product promise

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