Anti-Prune homolog 2 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prune homolog 2 also known as PRUNE2 is an enzyme that plays a mechanical role in cellular processes. It is part of the phosphoesterase family and has a molecular mass of approximately 337 kDa. PRUNE2 is expressed in various tissues but shows higher levels in the nervous system indicating its significance in neural function. This protein interacts with different cellular components facilitating various enzymatic activities necessary for cell maintenance and activity.

Biological function summary

This protein functions to regulate cell proliferation and migration which are essential in developmental and repair processes. PRUNE2 is often associated with cytoskeletal dynamics and acts as an important component in cellular signaling networks. It functions as part of several protein complexes where it modulates intracellular signals and influences cellular architecture and motility.

Pathways

PRUNE2 integrates into diverse cellular mechanisms by interacting with Wnt signaling and MAPK pathways. Both pathways are critical for transmitting signals that govern cell fate decisions and gene expression during growth and differentiation. PRUNE2 has shown interactions with proteins such as Dishevelled and ERK which are integral to these pathways confirming its role in transmitting important signals for cellular responses.

PRUNE2 is strongly linked to neurodegenerative diseases and certain cancer types. Alterations in the expression or function of PRUNE2 can contribute to Alzheimer's disease and glioblastomas. The protein shares connections with tau a protein associated with Alzheimer's pathology and EGFR often overexpressed in glioblastomas. These associations highlight PRUNE2's involvement in pathological conditions through its influence on cell signaling and structure integrity.