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AB2723

Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker

5

(15 Reviews)

|

(248 Publications)

Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody detecting PSD95 in Western Blot, IHC-P. Suitable for Mouse, Rat.

- Over 190 publications
- Trusted since 2003

View Alternative Names

Dlgh4, Psd95, Dlg4, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, PSD-95, SAP-90, SAP90

2 Images
Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)
  • WB

Project

Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)

All lanes:

Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 5 µg/mL

Lane 1:

Hippocampus (Rat) Tissue Lysate at 20 µg

Lane 2:

Forebrain (Rat) Tissue Lysate at 20 µg

Lane 3:

Hippocampus (Mouse) Tissue Lysate at 20 µg

Lane 4:

Forebrain (Mouse) Tissue Lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 80 kDa

Observed band size: 100 kDa,110 kDa,80 kDa,95 kDa

false

Exposure time: 3min

Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)
  • WB

AbReview44000****

Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)

All lanes:

Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 1/1200 dilution

Lanes 1 - 6:

Mouse Hippocampus at 30 µg

Lanes 7 - 12:

Mouse Liver at 30 µg

Secondary

All lanes:

Li-Cor IRDye® Donkey anti-mouse 680LT at 1/18000 dilution

Predicted band size: 80 kDa

Observed band size: 95 kDa

false

Exposure time: 5min

Image courtesy of an AbReview submitted by Grant Corbett

  • Carrier free

    Anti-PSD95 antibody [6G6-1C9] - BSA and Azide free

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6G6-1C9

Isotype

IgG2a

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

What is this antibody validated in?
Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse, Rat samples.

What is the molecular weight of PSD95?
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) specifically detects a band for PSD95 (UniProt: P31016) at a molecular weight of 80kDa.

Trusted by the scientific community
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) was first used in a scientific publication in 2003 and has been cited over 190 times in peer-reviewed journals.

Reviewed by scientists
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) has over 10 independent reviews from customers.

Other related products
We have a range of other formats of antibody clone [6G6-1C9] also available for your convenience: ab2723, Carrier free - ab264091

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed : 15358775, PubMed : 9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity).
See full target information Dlg4
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Publications (248)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 16:465 PubMed40867008

2025

Directed and efficient generation of calretinin interneurons from human pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xuewei Du,Renli Qi,Congge Li,Wenpei Zhou,Shijiao Wang,Shenxing Wei,Runzhong Wu,Yu Yin,Tianqing Li,Xiaoqing Zhu

NPJ Parkinson's disease 11:242 PubMed40804075

2025

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Lluis Miquel-Rio,Judith Jericó-Escolar,Unai Sarriés-Serrano,Claudia Yanes-Castilla,María Torres-López,Uxia Argibay,Verónica Paz,Carme Casal,Emma Muñoz-Moreno,Xavier López-Gil,Analia Bortolozzi

Scientific reports 15:25996 PubMed40676062

2025

Prenatal exposure to bisphenol A disrupts RNA splicing in the prefrontal cortex and promotes behaviors related to autism in offspring.

Applications

Unspecified application

Species

Unspecified reactive species

Pawinee Panjabud,Songphon Kanlayaprasit,Surangrat Thongkorn,Kwanjira Songsritaya,Pattanachat Lertpeerapan,Kasidit Kasitipradit,Thanawin Jantheang,Suthathip Sarobol,Thanit Saeliw,Valerie W Hu,Takeshi Imai,Tewarit Sarachana

British journal of pharmacology 182:5391-5408 PubMed40660634

2025

Scorpion venom heat-resistant synthetic peptide improves cognitive dysfunction of APP/PS1 mice through microglial retromer complex.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Zhang,Yu-Xia Wu,Xiao-Gang Zhang,Song-Yu Guo,Jia He,Na-Na Hu,Yue-Lin Huang,Yue Kong,Qi-Fa Li,Ao-Ran Sui,Bao-Hang Zhu,Hua Piao,Jie Zhao,Shao Li

Scientific reports 15:23764 PubMed40610652

2025

Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury.

Applications

Unspecified application

Species

Unspecified reactive species

Takuto Hanasaki,Keita Hanaki,Yukito Sako,Yasushi Uchiyama,Sachiko Lee-Hotta

Nature protocols : PubMed40579542

2025

Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes.

Applications

Unspecified application

Species

Unspecified reactive species

H M Arif Ullah,Qiju Huang,Simone Chiola,Yueqi Wang,Alex Shcheglovitov

iScience 28:112557 PubMed40502702

2025

Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β production.

Applications

Unspecified application

Species

Unspecified reactive species

Satoshi Morita,Takayuki Kondo,Hisanori Tokuda,Yoshihisa Kaneda,Takayuki Izumo,Yoshihiro Nakao,Haruhisa Inoue

Journal of neuroinflammation 22:81 PubMed40083008

2025

Sex chromosomes and gonads modify microglial-mediated pathology in a mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Brad T Casali,Li Lin,Olesia Benedict,Hannah Zuppe,Emily Marsico,Erin G Reed

Journal of neuroinflammation 22:71 PubMed40057769

2025

Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte Schubert,Kristina Schulz,Jana K Sonner,Alexandros Hadjilaou,Anna-Lena Seemann,Janine Gierke,Vanessa Vieira,Nina Meurs,Marcel S Woo,Christian Lohr,Fabio Morellini,Daniela Hirnet,Manuel A Friese

Metabolites 15: PubMed39852377

2025

The Comorbidity of Depression and Diabetes Is Involved in the Decidual Protein Induced by Progesterone 1 (Depp1) Dysfunction in the Medial Prefrontal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Xu,Mengxing Liao,Shize Zhang,Yuang Chen,Xinyue Shulai,Guangji Wang,Jiye Aa
View all publications
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Product promise

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