Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody that is used to detect PSD95 in Western Blot, IHC-P. Suitable for Mouse, Rat samples.
- Over 190 publications
- Trusted since 2003
Images
![Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723), expandable thumbnail](https://content.abcam.com/products/images/psd95-antibody-6g6-1c9-synaptic-marker-ab2723--western-blot-img93804.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)")
![Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723), expandable thumbnail](https://content.abcam.com/products/images/psd95-antibody-6g6-1c9-synaptic-marker-ab2723--western-blot-img17099.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (AB2723)")
Publications
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- Biomaterials research 27:1082023Nanoarchitectonics of tannic acid based injectable hydrogel regulate the microglial phenotype to enhance neuroplasticity for poststroke rehabilitation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZongjian Liu,Shulei Zhang,Yuanyuan Ran,Huimin Geng,Fuhai Gao,Guiqin Tian,Zengguo Feng,Jianing Xi,Lin Ye,Wei SuPubMed 37908012
- Frontiers in molecular neuroscience 16:12327952023AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHarrison J Ramsay,Sara E Gookin,Austin M Ramsey,Dean J Kareemo,Kevin C Crosby,Dominik G Stich,Samantha S Olah,Hannah S Actor-Engel,Katharine R Smith,Matthew J KennedyPubMed 37602191
- JCI insight 8:2023Restoring calcium homeostasis in Purkinje cells arrests neurodegeneration and neuroinflammation in the ARSACS mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrea Del Bondio,Fabiana Longo,Daniele De Ritis,Erica Spirito,Paola Podini,Bernard Brais,Angela Bachi,Angelo Quattrini,Francesca MalteccaPubMed 37159335
- Cells 12:2023Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHenry G S Martin,Dimitri M KullmannPubMed 37408217
- Heliyon 9:e158722023Efficacy of puerarin in rats with focal cerebral ischemia through modulation of the SIRT1/HIF-1α/VEGF signaling pathway and its effect on synaptic plasticity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Liu,Xiwen Sui,Yuqin Zhang,Rongchao Yue,Shifu YinPubMed 37223716
- Glia 71:1804-18292023Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKazi Atikur Rahman,Marta Orlando,Ayub Boulos,Ewa Andrzejak,Dietmar Schmitz,Noam E Ziv,Harald Prüss,Craig C Garner,Aleksandra IchkovaPubMed 37026600
- Journal of cell science 136:2023Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDanya Abazari,Angela R Wild,Tian Qiu,Bryan C Dickinson,Shernaz X BamjiPubMed 37039765
- Cellular and molecular life sciences : CMLS 80:822023Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaura Ferrer-Ferrer,Shaobo Jia,Rahul Kaushik,Jenny Schneeberg,Izabela Figiel,Stepan Aleshin,Andrey Mironov,Motahareh Safari,Renato Frischknecht,Jakub Wlodarczyk,Oleg Senkov,Alexander DityatevPubMed 36871239
- Antioxidants (Basel, Switzerland) 12:2023Mechanism of Action of Natural Compounds in Peripheral Multiorgan Dysfunction and Hippocampal Neuroinflammation Induced by Sepsis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRamona D'Amico,Mario Tomasello,Daniela Impellizzeri,Marika Cordaro,Rosalba Siracusa,Livia Interdonato,Ali Saber Abdelhameed,Roberta Fusco,Vittorio Calabrese,Salvatore Cuzzocrea,Rosanna Di PaolaPubMed 36978883
- Biological procedures online 25:42023A 3D human co-culture to model neuron-astrocyte interactions in tauopathies.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKevin L Batenburg,Claudia Sestito,Paulien Cornelissen-Steijger,Jan R T van Weering,Leo S Price,Vivi M Heine,Wiep ScheperPubMed 36814189
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 6.97% L-Arginine- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Mouse | Expected | Tested |
| Rat | Tested | Tested |
| Cow | Predicted | Predicted |
| Zebrafish | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1-2 µg/mL | Notes We do not guarantee IHC-P for mouse. Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1-5 µg/mL | Notes - |
Species Rat | Dilution info 1-5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
Associated Products
Select an associated product type
4 products for Alternative Product
1 product for Alternative Version
Target data
Function
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15358775, PubMed:9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity).
Alternative names
Dlgh4, Psd95, Dlg4, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, PSD-95, SAP-90, SAP90
Recommended products
Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody that is used to detect PSD95 in Western Blot, IHC-P. Suitable for Mouse, Rat samples.
- Over 190 publications
- Trusted since 2003
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 6.97% L-Arginine- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- 6G6-1C9
- Purification technique
- Affinity purification
- Specificity
We do not guarantee IHC-P for mouse.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse, Rat samples.
What is the molecular weight of PSD95?
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) specifically detects a band for PSD95 (UniProt: P31016) at a molecular weight of 80kDa.
Trusted by the scientific community
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) was first used in a scientific publication in 2003 and has been cited over 190 times in peer-reviewed journals.
Reviewed by scientists
Anti-PSD95 [6G6-1C9] - Synaptic Marker (ab2723) has over 10 independent reviews from customers.
Other related products
We have a range of other formats of antibody clone [6G6-1C9] also available for your convenience:
ab2723, Carrier free - Anti-PSD95 antibody [6G6-1C9] - BSA and Azide free ab264091
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723), expandable thumbnail](https://content.abcam.com/products/images/psd95-antibody-6g6-1c9-synaptic-marker-ab2723--western-blot-img93804.jpg "Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723)")
Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723)
All lanes: Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 5 µg/mL
Lane 1: Hippocampus (Rat) Tissue Lysate at 20 µg
Lane 2: Forebrain (Rat) Tissue Lysate at 20 µg
Lane 3: Hippocampus (Mouse) Tissue Lysate at 20 µg
Lane 4: Forebrain (Mouse) Tissue Lysate at 20 µg
SecondaryAll lanes: Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (Goat Anti-Mouse IgG H&L (HRP) preadsorbed ab97040) at 1/5000 dilution
Performed under reducing conditions.
Predicted band size: 80 kDa
Observed band size: 100 kDa, 110 kDa, 80 kDa, 95 kDa
Exposure time: 3min
![Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723), expandable thumbnail](https://content.abcam.com/products/images/psd95-antibody-6g6-1c9-synaptic-marker-ab2723--western-blot-img17099.jpg "Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723)")
Image courtesy of a customer review submitted by Grant CorbettWestern blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723)
All lanes: Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 1/1200 dilution
Lanes 1 - 6: Mouse Hippocampus at 30 µg with Li-Cor Block Buffer, 1 hour at 21°C
Lanes 7 - 12: Mouse Liver at 30 µg with Li-Cor Block Buffer, 1 hour at 21°C
SecondaryAll lanes: Li-Cor IRDye® Donkey anti-mouse 680LT at 1/18000 dilution
Performed under reducing conditions.
Predicted band size: 80 kDa
Observed band size: 95 kDa
Exposure time: 5min
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Product protocols
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- Visit troubleshooting
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