Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody that is used to detect PSD95 in Western Blot, IHC-P. Suitable for Mouse, Rat samples.
- Over 190 publications
- Trusted since 2003
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 6.97% L-Arginine
IHC-P | WB | |
---|---|---|
Mouse | Expected | Tested |
Rat | Tested | Tested |
Cow | Predicted | Predicted |
Zebrafish | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info 1-2 µg/mL | Notes We do not guarantee IHC-P for mouse. Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info 1-5 µg/mL | Notes - |
Species Rat | Dilution info 1-5 µg/mL | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Cow, Zebrafish | Dilution info - | Notes - |
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Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15358775, PubMed:9853749). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (Probable). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity).
Dlgh4, Psd95, Dlg4, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, PSD-95, SAP-90, SAP90
Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) is a mouse monoclonal antibody that is used to detect PSD95 in Western Blot, IHC-P. Suitable for Mouse, Rat samples.
- Over 190 publications
- Trusted since 2003
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 6.97% L-Arginine
We do not guarantee IHC-P for mouse.
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This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
All lanes: Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 5 µg/mL
Lane 1: Hippocampus (Rat) Tissue Lysate at 20 µg
Lane 2: Forebrain (Rat) Tissue Lysate at 20 µg
Lane 3: Hippocampus (Mouse) Tissue Lysate at 20 µg
Lane 4: Forebrain (Mouse) Tissue Lysate at 20 µg
All lanes: Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (Goat Anti-Mouse IgG H&L (HRP) preadsorbed ab97040) at 1/5000 dilution
Performed under reducing conditions.
Predicted band size: 80 kDa
Observed band size: 100 kDa, 110 kDa, 80 kDa, 95 kDa
Exposure time: 3min
All lanes: Western blot - Anti-PSD95 antibody [6G6-1C9] - Synaptic Marker (ab2723) at 1/1200 dilution
Lanes 1 - 6: Mouse Hippocampus at 30 µg with Li-Cor Block Buffer, 1 hour at 21°C
Lanes 7 - 12: Mouse Liver at 30 µg with Li-Cor Block Buffer, 1 hour at 21°C
All lanes: Li-Cor IRDye® Donkey anti-mouse 680LT at 1/18000 dilution
Performed under reducing conditions.
Predicted band size: 80 kDa
Observed band size: 95 kDa
Exposure time: 5min
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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