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AB76108

Anti-PSD95 (phospho S295) antibody [EP2615Y]

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(6 Publications)

Rabbit Monoclonal PSD95 phospho S295 antibody. Suitable for WB and reacts with Human, Rat samples. Cited in 6 publications.

View Alternative Names

PSD95, DLG4, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, PSD-95, SAP-90, SAP90

1 Images
Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (AB76108)
  • WB

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Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (AB76108)

All lanes:

Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (ab76108) at 1/20000 dilution

Lane 1:

Human brain tissue lysate, treated with LP

Lane 2:

Human brain tissue lysate untreated

Lane 3:

Rat brain lysate, treated with LP

Lane 4:

Rat brain lysate, untreated

Predicted band size: 80 kDa

Observed band size: 95 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP2615Y

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed : 26334723).
See full target information DLG4 phospho S295
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 45: PubMed40335156

2025

CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity.

Applications

Unspecified application

Species

Unspecified reactive species

Chunta Ho,Jared Luchetta,Bradley Nash,Lindsay K Festa,James A Johnson,Ahmet Sacan,Joshua G Jackson,Antonio Sanz-Clemente,Renato Brandimarti,Olimpia Meucci

Cell reports 43:113680 PubMed38241148

2024

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Zhi Wang,Charlotte C M Castillon,Kamil K Gebis,Elizabeth T Bartom,Alessandra d'Azzo,Anis Contractor,Jeffrey N Savas

Brain : a journal of neurology 143:2709-2720 PubMed32830245

2020

Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.

Applications

Unspecified application

Species

Unspecified reactive species

Francesco Mannara,Marija Radosevic,Jesús Planagumà,David Soto,Esther Aguilar,Anna García-Serra,Estibaliz Maudes,Marta Pedreño,Steven Paul,James Doherty,Michael Quirk,Jing Dai,Xavier Gasull,Mike Lewis,Josep Dalmau

Experimental neurology 289:31-45 PubMed27993509

2016

Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Vsevolod Bodrikov,Aline Pauschert,Gaga Kochlamazashvili,Claudia A O Stuermer

Molecular medicine reports 13:5248-54 PubMed27122047

2016

Neuroprotective effects of resveratrol against traumatic brain injury in rats: Involvement of synaptic proteins and neuronal autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Feng,Ying Cui,Jun-Ling Gao,Ran Li,Xiao-Hua Jiang,Yan-Xia Tian,Kai-Jie Wang,Ming-Hang Li,Hong-Ao Zhang,Jian-Zhong Cui

Proceedings of the National Academy of Sciences of 110:9118-23 PubMed23671101

2013

Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.

Applications

Unspecified application

Species

Unspecified reactive species

Yong-Chuan Zhu,Dan Li,Lu Wang,Bin Lu,Jing Zheng,Shi-Lin Zhao,Rong Zeng,Zhi-Qi Xiong
View all publications
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