Rabbit Monoclonal PSD95 phospho S295 antibody. Suitable for WB and reacts with Human, Rat samples. Cited in 4 publications.
Images
![Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (AB76108), expandable thumbnail](https://content.abcam.com/products/images/psd95-phospho-s295-antibody-ep2615y-ab76108--western-blot-img17120.gif "Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (AB76108)")
Publications
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- Brain : a journal of neurology 143:2709-27202020Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancesco Mannara,Marija Radosevic,Jesús Planagumà,David Soto,Esther Aguilar,Anna García-Serra,Estibaliz Maudes,Marta Pedreño,Steven Paul,James Doherty,Michael Quirk,Jing Dai,Xavier Gasull,Mike Lewis,Josep DalmauPubMed 32830245
- Experimental neurology 289:31-452016Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVsevolod Bodrikov,Aline Pauschert,Gaga Kochlamazashvili,Claudia A O StuermerPubMed 27993509
- Molecular medicine reports 13:5248-542016Neuroprotective effects of resveratrol against traumatic brain injury in rats: Involvement of synaptic proteins and neuronal autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Feng et. al.PubMed 27122047
- Proceedings of the National Academy of Sciences of 110:9118-232013Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYong-Chuan Zhu et. al.PubMed 23671101
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Abcam Recommends
Reactivity data
Select an application| Flow Cyt | WB | IHC-P | |
|---|---|---|---|
| Human | Not recommended | Tested | Not recommended |
| Mouse | Not recommended | Predicted | Not recommended |
| Rat | Not recommended | Tested | Not recommended |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Human, Mouse | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/10000.00000 - 1/50000.00000 | Notes - |
Species Rat | Dilution info 1/10000.00000 - 1/50000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Human, Mouse | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723).
Alternative names
PSD95, DLG4, Disks large homolog 4, Postsynaptic density protein 95, Synapse-associated protein 90, PSD-95, SAP-90, SAP90
Recommended products
Rabbit Monoclonal PSD95 phospho S295 antibody. Suitable for WB and reacts with Human, Rat samples. Cited in 4 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EP2615Y
- Purity
- Tissue culture supernatant
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (ab76108)
All lanes: Western blot - Anti-PSD95 (phospho S295) antibody [EP2615Y] (ab76108) at 1/20000 dilution
Lane 1: Human brain tissue lysate, treated with LP
Lane 2: Human brain tissue lysate untreated
Lane 3: Rat brain lysate, treated with LP
Lane 4: Rat brain lysate, untreated
Predicted band size: 80 kDa
Observed band size: 95 kDa
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