Anti-PSMD14 antibody [EPR4258] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PSMD14 also known as POH1 or RPN11 is a proteasome subunit involved in the regulation of protein degradation. This protein has a molecular mass of approximately 34 kDa and forms an essential part of the 19S regulatory particle of the proteasome complex. PSMD14 is expressed in various tissues but shows significant expression levels in the brain heart and skeletal muscles. By deubiquitinating substrates PSMD14 contributes to the recycling of ubiquitin for further use in the cell’s ubiquitin-proteasome pathway.

Biological function summary

PSMD14 functions as a vital component of the 19S proteasome which is integrated into the proteolytic 26S proteasome complex. The protein's deubiquitinating activity plays a role in maintaining proteostasis by removing ubiquitin chains from substrates destined for degradation. This process is important for regulating protein quality control cell cycle progression and response to oxidative stress among other cellular processes. As part of the proteasome complex PSMD14’s activity impacts cellular homeostasis and contributes to cellular responses to various stimuli.

Pathways

PSMD14 is instrumental in the ubiquitin-proteasome system which is essential for targeted protein degradation modulation of the cell cycle and regulation of transcription factors. It interacts with other proteasome components like PSMD12 and PSMD3 to form a functional proteasome unit. This protein is significant in the NF-kB signaling pathway where it influences the degradation of inhibitor proteins allowing for the activation of NF-kB a critical transcription factor in immune response and cell survival.

Associated diseases and disorders

PSMD14’s function connects it to cancer and neurodegenerative conditions. Deregulation or mutations in PSMD14 have been implicated in various cancers possibly through disturbed protein degradation which leads to aberrant cell cycle progression and survival. It also relates to neurodegenerative diseases like Alzheimer's as impaired proteasome function can lead to the accumulation of misfolded proteins. PSMD14 interacts with proteins like UCH37 which is also linked to the pathogenesis of these diseases highlighting the significance of controlled proteolysis in maintaining cellular health.