Anti-PSMD6 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PSMD6 also known as Proteasome 26S Subunit Non-ATPase 6 is an essential protein component of the 26S proteasome. Its molecular weight is approximately 37 kDa. The proteasome system where PSMD6 plays a critical role is responsible for the regulated degradation of ubiquitinated proteins which affects various cellular processes. This subunit predominantly locates in the cytoplasm and the nucleus where high proteasome activity is required such as in the heart liver and skeletal muscle cells.

Biological function summary

PSMD6 functions in the context of the proteasome complex's regulatory particle as it assists in maintaining protein homeostasis by recognizing and processing ubiquitin-tagged proteins. This process is fundamental for the proteins' degradation influencing cell cycle progression apoptosis and DNA repair. It ensures cellular quality control and adaptation to changing conditions. PSMD6 by participating in this mechanism indirectly supports the regulation of numerous cellular activities important for maintaining specific cellular functions.

Pathways

PSMD6 integrates into ubiquitin-proteasome pathways important for protein turnover and signaling transduction. It interacts with other proteasome subunits and related proteins like PSMD1 and PSMD2 in these pathways. The ubiquitin-proteasome system is pivotal for controlling protein levels involved in cell cycle regulation and signal transduction pathways such as the NF-kB signaling pathway. Alterations in these pathways might lead to disrupted cellular regulation causing various pathophysiological outcomes.

Associated diseases and disorders

PSMD6 links to certain pathological conditions including cancer and neurodegenerative disorders. Abnormal proteasome activity where PSMD6 contributes often correlates with tumorigenesis as improper protein degradation can lead to uncontrolled cell proliferation. Furthermore changes in PSMD6 expression or function can associate with Alzheimer's disease where proteasome dysfunction results in the accumulation of misfolded or damaged proteins contributing to neurodegeneration. PSMD6 interacts with proteins such as ubiquitin and other proteasome subunits influencing these disease processes.