AB155761

Anti-PSMD6 antibody

Name: Anti-PSMD6 antibody (ab155761) | Abcam
Brand: Abcam Limited
SKU: AB155761
Price: 495 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal PSMD6 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSMD6 aa 1-350.

View Alternative Names

KIAA0107, PFAAP4, PSMD6, 26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit RPN7, 26S proteasome regulatory subunit S10, Breast cancer-associated protein SGA-113M, Phosphonoformate immuno-associated protein 4, Proteasome regulatory particle subunit p44S10, p42A

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMD6 antibody (AB155761)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMD6 antibody (AB155761)

Immunohistochemical analysis of paraffin-embedded mouse fore brain tissue labelling PSMD6 protein at nucleus with ab155761 at a 1/500 dilution.

Antigen retrieval : Trilogy™ (EDTA based, pH 8.0) buffer, 15min

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMD6 antibody (AB155761)

Immunohistochemical analysis of paraffin-embedded rat fore brain tissue labelling PSMD6 protein at nucleus with ab155761 at a 1/500 dilution.

Antigen retrieval : Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Unknown

Western blot - Anti-PSMD6 antibody (AB155761)

10% SDS PAGE

All lanes:

Western blot - Anti-PSMD6 antibody (ab155761) at 1/1000 dilution

Lane 1:

Jurkat whole cell lysate at 30 µg

Lane 2:

Raji whole cell lysate at 30 µg

Lane 3:

K562 whole cell lysate at 30 µg

Lane 4:

THP-1 whole cell lysate at 30 µg

Predicted band size: 46 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PSMD6 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q15008

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PSMD6 also known as Proteasome 26S Subunit Non-ATPase 6 is an essential protein component of the 26S proteasome. Its molecular weight is approximately 37 kDa. The proteasome system where PSMD6 plays a critical role is responsible for the regulated degradation of ubiquitinated proteins which affects various cellular processes. This subunit predominantly locates in the cytoplasm and the nucleus where high proteasome activity is required such as in the heart liver and skeletal muscle cells.

Biological function summary

PSMD6 functions in the context of the proteasome complex's regulatory particle as it assists in maintaining protein homeostasis by recognizing and processing ubiquitin-tagged proteins. This process is fundamental for the proteins' degradation influencing cell cycle progression apoptosis and DNA repair. It ensures cellular quality control and adaptation to changing conditions. PSMD6 by participating in this mechanism indirectly supports the regulation of numerous cellular activities important for maintaining specific cellular functions.

Pathways

PSMD6 integrates into ubiquitin-proteasome pathways important for protein turnover and signaling transduction. It interacts with other proteasome subunits and related proteins like PSMD1 and PSMD2 in these pathways. The ubiquitin-proteasome system is pivotal for controlling protein levels involved in cell cycle regulation and signal transduction pathways such as the NF-kB signaling pathway. Alterations in these pathways might lead to disrupted cellular regulation causing various pathophysiological outcomes.

PSMD6 links to certain pathological conditions including cancer and neurodegenerative disorders. Abnormal proteasome activity where PSMD6 contributes often correlates with tumorigenesis as improper protein degradation can lead to uncontrolled cell proliferation. Furthermore changes in PSMD6 expression or function can associate with Alzheimer's disease where proteasome dysfunction results in the accumulation of misfolded or damaged proteins contributing to neurodegeneration. PSMD6 interacts with proteins such as ubiquitin and other proteasome subunits influencing these disease processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

See full target information PSMD6

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

World journal of clinical oncology 16:99839 PubMed39995557

2025

Overexpression pattern, function, and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sheng-Sheng Zhou,Yu-Ping Ye,Yi Chen,Da-Tong Zeng,Guang-Cai Zheng,Rong-Quan He,Bang-Teng Chi,Lei Wang,Qian Lin,Qin-Yan Su,Yi-Wu Dang,Gang Chen,Jia-Liang Wei

World journal of hepatology 16:1282-1289 PubMed39606161

2024

Overexpression of proteasome 26S subunit non-ATPase 6 protein and its clinicopathological significance in intrahepatic cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong-Qing Tang,Yu-Lu Tang,Kai Qin,Qi Li,Gang Chen,Yu-Bin Huang,Jian-Jun Li

Molecular medicine reports 31: PubMed39540371

2024

Dental pulp stem cell‑derived extracellular vesicles loaded with hydrogels promote osteogenesis in rats with alveolar bone defects.

Applications

Unspecified application

Species

Unspecified reactive species

Xin He,Xiao-Yang Chu,Xu Chen,Yu-Lan Xiang,Ze-Lu Li,Chun-Yan Gao,Ying-Yi Luan,Kai Yang,Dong-Liang Zhang

Biomolecules 13: PubMed37371572

2023

Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Shirel Steinberger,Julia Adler,Yosef Shaul

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PSMD6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMD6 antibody (AB155761)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSMD6 antibody (AB155761)

Western blot - Anti-PSMD6 antibody (AB155761)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise