AB178417

Anti-PSMD7/Mov34 antibody [EPR13516(B)]

RabMAb
Recombinant
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(3 Publications)

Rabbit Recombinant Monoclonal PSMD7/Mov34 antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.

View Alternative Names

MOV34L, PSMD7, 26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit RPN8, 26S proteasome regulatory subunit S12, Mov34 protein homolog, Proteasome subunit p40

3 Images

Flow Cytometry (Intracellular) - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Intracellular flow cytometric analysis of permeabilized K562 cells labeling PSMD7/Mov34 with ab178417 at 1/10 dilution (red) compared with a rabbit IgG negative control (green).

Supplier Data

Immunoprecipitation - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Western blot analysis on immunoprecipitation pellet from K562 cell lysate immunoprecipitated using ab178417 at 1/10 dilution.

All lanes:

Immunoprecipitation - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (ab178417)

Predicted band size: 37 kDa

false

Supplier Data

Western blot - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

All lanes:

Western blot - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (ab178417) at 1/1000 dilution

Lane 1:

HepG2 cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

K562 cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13516(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IP, Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PSMD7 protein also known as Mov34 is a subunit of the 26S proteasome and plays an important role in protein degradation. The proteasome itself is a massive complex and PSMD7 is a 37 kDa protein component. Its primary site of expression is within the cytoplasm and nucleus of cells where it facilitates the breakdown of ubiquitinated proteins. This activity is essential for maintaining cellular protein homeostasis.

Biological function summary

The proper function of PSMD7 supports cell cycle regulation apoptosis and DNA damage repair. It exists as part of the 26S proteasome complex which is responsible for the regulated degradation of ubiquitin-conjugated proteins. This process controls various cellular mechanisms by ensuring that proteins are broken down after they have executed their function or if they become misfolded or damaged.

Pathways

The involvement of PSMD7 in proteolysis is central for processes such as the ubiquitin-proteasome pathway. This pathway is critical for protein turnover and the regulation of cellular processes including the cell cycle. PSMD7 works in tandem with other proteasomal subunits like PSMD4 and PSMD14 which help recruit and process ubiquitinated substrates.

The malfunction of PSMD7 associates with certain cancers and neurodegenerative diseases. Aberrations in proteasome function involving PSMD7 may lead to the accumulation of damaged proteins which contributes to cancer development through unchecked cell proliferation. In neurodegenerative disorders like Alzheimer's disease proteins like tau and beta-amyloid which should normally be degraded accumulate due to proteasomal dysfunction involving PSMD7.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

See full target information PSMD7

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 224: PubMed39907656

2025

VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b.

Applications

Unspecified application

Species

Unspecified reactive species

Paolo Sanzà,Jan van der Beek,Derk Draper,Cecilia de Heus,Tineke Veenendaal,Corlinda Ten Brink,Ginny G Farías,Nalan Liv,Judith Klumperman

Clinical and translational medicine 15:e70118 PubMed39731281

2024

The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity.

Applications

Unspecified application

Species

Unspecified reactive species

Ao Duan,Zemeng Ma,Xiaolong Shao,Zhencheng Xiong,Chaoyi Zhang,Wenzheng Liu,Guanglin Wang,Shouye Hu,Wei Lin

Bioengineered 13:2525-2536 PubMed35037550

2022

Transcriptional activation of Proteasome 26S non-ATPase subunit 7 by forkhead box P3 participates in gastric cancer cell proliferation and apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Xu,Dingmao Wang,Guodong Zhao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PSMD7/Mov34 antibody [EPR13516(B)]

Flow Cytometry (Intracellular) - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Immunoprecipitation - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Western blot - Anti-PSMD7/Mov34 antibody [EPR13516(B)] (AB178417)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise