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AB3333

Anti-PSME1 antibody

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(5 Publications)

Rabbit Polyclonal PSME1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human PSME1 aa 1-50.

View Alternative Names

IFI5111, PSME1, Proteasome activator complex subunit 1, 11S regulator complex subunit alpha, Activator of multicatalytic protease subunit 1, Interferon gamma up-regulated I-5111 protein, Proteasome activator 28 subunit alpha, REG-alpha, IGUP I-5111, PA28a, PA28alpha

1 Images
Western blot - Anti-PSME1 antibody (AB3333)
  • WB

Unknown

Western blot - Anti-PSME1 antibody (AB3333)

Western blot detection of PSME1 in Hepa 1 cell lysate using ab3333.

All lanes:

Western blot - Anti-PSME1 antibody (ab3333)

Predicted band size: 29 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PSME1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q06323

Specificity

Detects PSME1 (proteasome activator complex subunit 1).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>By Western blot, this antibody detects a 28 kDa protein representing PSME1 in rat brain extract.</p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PSME1 also known as PA28α (proteasome activator complex subunit 1) is a protein that functions as a regulatory component of the 20S proteasome. It has a molecular weight of approximately 28 kDa. This protein is expressed in various tissues with noticeable expression in immune-related tissues such as the spleen and thymus. PSME1 binds to proteasome core particles and modifies their activity by opening access to their catalytic core honing the degradation of ubiquitinated proteins.
Biological function summary

PSME1 modulates protein degradation processes and participates as a component of the immunoproteasome. The immunoproteasome is a complex that processes peptides for presentation on MHC class I molecules vital for immune response. This involvement transforms PSME1 into an important player in antigen processing and presentation influencing T-cell activation and immune surveillance. PSME1 affects immune system adaptability and efficiency impacting infection response and immune regulation.

Pathways

PSME1 is a significant participant in the ubiquitin-proteasome system and the MHC class I antigen processing pathway. It directly interacts with other proteasome components like the catalytic 20S core and the 11S regulator. The interplay with these proteins steers the precision and output of antigenic peptides essential for T-cell mediated immune recognition. By influencing these pathways PSME1 links the protein degradation machinery to adaptive immunity.

PSME1 has connections to autoimmune diseases and cancers. Alterations in its function or expression can disrupt regular proteasome activity leading to improper immune responses such as in autoimmune pathologies like systemic lupus erythematosus. Furthermore PSME1's role in antigen processing intersects with other proteins such as TAP1 affecting immune evasion strategies seen in certain cancers. These interactions suggest that PSME1 is a contributor in both immune-related health issues and cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
See full target information PSME1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in endocrinology 14:1176733 PubMed37201100

2023

The role of proteasome activators PA28αβ and PA200 in brown adipocyte differentiation and function.

Applications

Unspecified application

Species

Unspecified reactive species

Zeynep Koçberber,Nienke Willemsen,Alexander Bartelt

Communications biology 4:1091 PubMed34531530

2021

TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.

Applications

Unspecified application

Species

Unspecified reactive species

Maren Hülsemann,Colline Sanchez,Polina V Verkhusha,Vera Des Marais,Serena P H Mao,Sara K Donnelly,Jeffrey E Segall,Louis Hodgson

The Journal of cell biology 216:4331-4349 PubMed29061650

2017

Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Sara K Donnelly,Ramon Cabrera,Serena P H Mao,John R Christin,Bin Wu,Wenjun Guo,Jose Javier Bravo-Cordero,John S Condeelis,Jeffrey E Segall,Louis Hodgson

Cancer immunology research 3:1218-26 PubMed26112922

2015

Neutrophils Increase Oral Squamous Cell Carcinoma Invasion through an Invadopodia-Dependent Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Judah E Glogauer,Chun X Sun,Grace Bradley,Marco A O Magalhaes

Cell death & disease 5:e1066 PubMed24556681

2014

TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain.

Applications

WB

Species

Mouse

A Pla,M Pascual,J Renau-Piqueras,C Guerri
View all publications
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Product promise

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