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AB96845

Anti-PSMF1 antibody

4

(1 Review)

|

(1 Publication)

Rabbit Polyclonal PSMF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Proteasome inhibitor PI31 subunit aa 200 to C-terminus.

View Alternative Names

Proteasome inhibitor PI31 subunit, hPI31, PSMF1

1 Images
Western blot - Anti-PSMF1 antibody (AB96845)
  • WB

Unknown

Western blot - Anti-PSMF1 antibody (AB96845)

12% SDS-PAGE.

All lanes:

Western blot - Anti-PSMF1 antibody (ab96845) at 1/1000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 30 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human Proteasome inhibitor PI31 subunit aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92530

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Alternative Products

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PSMF1 also known as proteasome inhibitor subunit 1 or PI31 inhibits the proteasome a protein complex responsible for degrading unwanted or damaged proteins through ubiquitin-proteasome pathway. PSMF1 has a mass of approximately 29 kDa and shows expression in a variety of human tissues with notable presence in the liver brain and testis. Its role as an inhibitor allows regulation of proteasomal activity playing important part in maintaining protein homeostasis.
Biological function summary

PSMF1 interacts with proteasomal subunits functioning within the core particle of the 20S proteasome complex. Its inhibitory action helps balance protein degradation in cells impacting processes such as cell cycle apoptosis and stress responses. The modulating effect of PSMF1 on the proteasome distinguishes its role in cellular regulatory mechanisms.

Pathways

PSMF1 contributes to the ubiquitin-proteasome pathway and influences the NF-kB signaling pathway. PSMF1's interactions within this system connect it with other essential proteins including ubiquitin which mark proteins for degradation and the proteasome the complex where degradation occurs. This process affects the transcription factor NF-kB which regulates genes involved in immune response and inflammation.

PSMF1 has been associated with cancer and neurodegenerative diseases like Parkinson’s disease. In cancer its role in regulating proteasome activity impacts cellular proliferation and survival connecting it to other proteins such as p53 involved in tumor suppression. In neurodegenerative disorders impaired proteasome function links PSMF1 to the accumulation of misfolded proteins with proteins like alpha-synuclein involved in the pathology of conditions such as Parkinson’s disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
See full target information Proteasome inhibitor PI31 subunit
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 19:1781-1802 PubMed36541703

2022

PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas D Demers,Victoria Riccio,Doo Sin Jo,Sushil Bhandari,Kelsey B Law,Weifang Liao,Choy Kim,G Angus McQuibban,Seong-Kyu Choe,Dong-Hyung Cho,Peter K Kim
View all publications
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Product promise

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