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AB249738

Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free

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Rabbit Recombinant Monoclonal Psoriasin antibody. Carrier free. Suitable for IP, WB and reacts with Human, Recombinant full length protein samples.

View Alternative Names

PSOR1, S100A7C, S100A7, Protein S100-A7, Psoriasin, S100 calcium-binding protein A7

3 Images
Immunoprecipitation - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)
  • IP

Supplier Data

Immunoprecipitation - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)

This data was developed using ab172966, the same antibody clone in a different buffer formulation.

Western blot analysis on immunoprecipitation pellet from A431 cell lysate using ab172966.

All lanes:

Immunoprecipitation - Anti-Psoriasin antibody [EPR10433(2)] (<a href='/en-us/products/primary-antibodies/psoriasin-antibody-epr104332-ab172966'>ab172966</a>)

Predicted band size: 11 kDa

false

Western blot - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)
  • WB

Supplier Data

Western blot - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)

This data was developed using ab172966, the same antibody clone in a different buffer formulation.

All lanes:

Western blot - Anti-Psoriasin antibody [EPR10433(2)] (<a href='/en-us/products/primary-antibodies/psoriasin-antibody-epr104332-ab172966'>ab172966</a>) at 1/1000 dilution

Lane 1:

Human pancreas lysate at 10 µg

Lane 2:

A431 cell lysate at 10 µg

Lane 3:

MDA-MB-435 cell lysate at 10 µg

Predicted band size: 11 kDa

false

Western blot - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)
  • WB

Lab

Western blot - Anti-Psoriasin antibody [EPR10433(2)] - BSA and Azide free (AB249738)

This data was developed using ab172966, the same antibody clone in a different buffer formulation.

Lane 1:

Western blot - Anti-Psoriasin antibody [EPR10433(2)] (<a href='/en-us/products/primary-antibodies/psoriasin-antibody-epr104332-ab172966'>ab172966</a>) at 1/1000 dilution

Lane 2:

Western blot - Anti-Psoriasin antibody [EPR10433(2)] (<a href='/en-us/products/primary-antibodies/psoriasin-antibody-epr104332-ab172966'>ab172966</a>) at 1/10000 dilution

All lanes:

Full length recombinant protein tagged GST

Predicted band size: 11 kDa

Observed band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10433(2)

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Recombinant full length protein": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

ab249738 is the carrier-free version of ab172966.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Compatibility
This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Psoriasin also known as S100A7 is a member of the S100 protein family. It has a molecular mass of approximately 11.4 kDa. This protein exhibits calcium binding properties that influence its function. Psoriasin primarily expresses in keratinocytes which are predominant in the epidermis of the skin. Additionally it appears in various epithelia like mucous membranes. The expression levels rise in certain skin conditions suggesting it has a role in skin physiology.
Biological function summary

Psoriasin acts as an antimicrobial peptide contributing to the skin’s defense system against microbial invasion. It helps in controlling the growth of bacteria like E. coli and fungi. The protein does not function as part of a larger complex. Instead it operates independently to maintain the integrity of the skin barrier. Psoriasin also shows involvement in the inflammatory response of the skin where it interact with other immune system players.

Pathways

Several biological systems involve psoriasin including inflammation and skin homeostasis pathways. It interacts closely with other S100 proteins such as S100A8 and S100A9 which are part of the inflammatory process. These interactions can regulate immune cell migration and cytokine production highlighting its active role in modulating skin immune responses. Psoriasin serves as an important component in maintaining the balance between immune protection and inflammation within these pathways.

Psoriasin associates with psoriasis and breast cancer. In psoriasis it significantly increases aligning with its role in inflammation and skin barrier maintenance. The upregulation of psoriasin in psoriasis has been linked to overexpression of related proteins like S100A8 contributing to the chronic inflammatory state. In breast cancer particularly in certain carcinoma contexts its presence suggests a role in cancer cell survival. Researchers study its interaction with proteins in the cancer microenvironment to better understand its influence on tumor progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information S100A7
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com