Rabbit Polyclonal PSPC1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSPC1 aa 1-200.
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Publications
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- Scientific reports 11:140012021The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShiyu Li,Shuting Liu,Zhenning Dai,Qian Zhang,Yichao Xu,Youyu Chen,Zhenyou Jiang,Wenhua Huang,Hanxiao SunPubMed 34234233
- Cancer management and research 13:3281-32912021The Prognosis Value of PSPC1 Expression in Nasopharyngeal Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuocong He,Lurong Zhang,Keyu Lin,Zhengrong Huang,Yan Zhou,Shaojun Lin,Ying Su,Jianru PanPubMed 33883941
- Arteriosclerosis, thrombosis, and vascular biology 41:1428-14452021Knockout of the Gene Inhibits Neointima Formation in a Mouse Model of Vascular Injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXingli Xu (徐兴丽),Xinghua Xu (徐兴华),Yang Mao (毛洋),Lin Lu (卢琳),Jing Ma (马静),Tengfei Zheng (郑腾飞),Jie Zhang (张杰),Meng Zhang (章萌),Linlin Meng (孟霖霖),Lianyue Ma (马连越),Jing Cheng (程晶),Wenqiang Chen (陈文强),Hong Jiang (姜虹),Yun Zhang (张运),Cheng Zhang (张澄)PubMed 33626912
- Cell biology international 44:166-1762019RNA-binding protein SFPQ cooperates with HDAC1 to suppress CD40 transcription in pulmonary adventitial fibroblasts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan-Yun Pan,Jin-Xiu Yang,Wei Mao,Xing-Xiang WangPubMed 31393052
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PSPC1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WXF1
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Expected | Tested |
| Rat | Expected | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
Species Rat | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Alternative names
PSP1, PSPC1, Paraspeckle component 1, Paraspeckle protein 1
Recommended products
Rabbit Polyclonal PSPC1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSPC1 aa 1-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PSPC1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8WXF1
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PSPC1 also known as Paraspeckle Component 1 is a nuclear RNA-binding protein with a mass of approximately 53 kDa. This protein plays an important mechanical role in the formation of paraspeckles subnuclear structures involved in RNA processing and regulation. PSPC1 predominantly localizes in the nucleus and associates with non-coding RNAs such as NEAT1 contributing to nuclear body dynamics. Though present in several tissues its expression is notably high in testis and embryonic stem cells reflecting its roles in cellular processes.
- Biological function summary
PSPC1 participates in the regulation of gene expression by modulating the transcriptional activity and stability of specific RNAs. It functions as part of a larger RNA-protein complex that involves core paraspeckle proteins such as NONO and SFPQ. This complex helps in retaining hyper-edited RNAs within the nucleus preventing them from undergoing translation or degradation. By doing so PSPC1 influences cellular stress responses and development among other biological processes.
- Pathways
PSPC1 integrates into the cellular landscape by impacting the RNA processing and nuclear organization pathways. It maintains RNA homeostasis and transcript diversity acting synergistically with related proteins like NONO and SFPQ. Within the context of these pathways paraspeckle-associated activities involve RNA editing and sequestration linking PSPC1 to critical cellular functions such as transcriptional regulation and response to environmental changes.
- Associated diseases and disorders
PSPC1's association with various conditions occurs through its regulatory mechanisms in gene expression. Aberrations in PSPC1 expression or function may contribute to cancer progression particularly in prostate cancer by influencing oncogenic signaling pathways. Moreover its interactions with other proteins such as NONO can impact neurodegenerative disorders through altered RNA metabolism and neuronal gene expression. Understanding PSPC1's roles aids in developing targeted therapies for these conditions by modulating its function or associated pathways.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-PSPC1 antibody (ab184123)
7.5% SDS PAGE
All lanes: Western blot - Anti-PSPC1 antibody (ab184123) at 1/2000 dilution
Lane 1: 293T whole cell lysate at 30 µg
Lane 2: Hela whole cell lysate at 30 µg
Lane 3: HepG2 whole cell lysate at 30 µg
Predicted band size: 59 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSPC1 antibody (ab184123)
Immunohistochemical analysis of paraffin-embedded rat fore brain labeling PSPC1 with ab184123 at 1/500 dilution
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSPC1 antibody (ab184123)
Immunohistochemical analysis of paraffin-embedded mouse hind brain labeling PSPC1 with ab184123 at 1/500 dilution
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