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AB187199

Anti-PSRC1/DDA3 antibody

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(2 Publications)

Rabbit Polyclonal PSRC1/DDA3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSRC1 aa 1-250.

View Alternative Names

DDA3, FP3214, PSRC1, Proline/serine-rich coiled-coil protein 1

1 Images
Western blot - Anti-PSRC1/DDA3 antibody (AB187199)
  • WB

Supplier Data

Western blot - Anti-PSRC1/DDA3 antibody (AB187199)

All lanes:

Western blot - Anti-PSRC1/DDA3 antibody (ab187199) at 1/500 dilution

Lane 1:

MCF-7 cell extract

Lane 2:

HepG2 cell extract

Lane 3:

293T cell extract

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PSRC1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q6PGN9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PSRC1 protein also known as DDA3 plays an important role in cell cycle regulation. It is a microtubule-associated protein with a mass of approximately 33 kDa. PSRC1 is widely expressed in various tissues including the brain heart and liver. It interacts directly with microtubule plus-end tracking proteins and regulates microtubule dynamics which is essential for proper mitotic spindle function.
Biological function summary

PSRC1 plays an important role in ensuring correct chromosome segregation during cell division. It functions as part of the mitotic spindle assembly complex and is responsible for promoting stable attachment of microtubules to kinetochores which is critical for accurate chromosomal alignment. These functions involve interactions with proteins related to spindle formation and checkpoint signaling.

Pathways

PSRC1 acts in the mitotic spindle checkpoint pathway and the microtubule dynamics pathway. Its interaction with proteins like CLASP1 and APC important for microtubule stability and dynamics highlights its contribution to maintaining proper mitotic progression. PSRC1 ensures successful completion of mitosis by coordinating these pathways important for cell division fidelity.

PSRC1 connects to various types of cancer such as breast and colorectal cancer. It influences tumor progression through its effect on cell division errors and genomic instability. Additionally PSRC1 interacts with TP53 a protein responsible for cell cycle regulation and apoptosis suggesting its potential role in tumor suppression mechanisms compromised in cancerous conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
See full target information PSRC1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology research 33:133-148 PubMed39735680

2024

CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Sun,Qinghua Song,Hua Liu

The EMBO journal 39:e104870 PubMed32896909

2020

HIV-1 capsids mimic a microtubule regulator to coordinate early stages of infection.

Applications

Unspecified application

Species

Unspecified reactive species

Eveline Santos da Silva,Shanmugapriya Shanmugapriya,Viacheslav Malikov,Feng Gu,M Keegan Delaney,Mojgan H Naghavi
View all publications
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Product promise

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