Rabbit Polyclonal PSTPIP2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus.
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Publications
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- European journal of pharmacology 859:1725582019PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYao Yao et. al.PubMed 31325437
- Oncogene 37:6119-61352018PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Yang et. al.PubMed 29993036
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H939
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Expected | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Alternatively Tris-EDTA buffer (pH8.0) may be used. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Alternative names
Proline-serine-threonine phosphatase-interacting protein 2, PEST phosphatase-interacting protein 2, PSTPIP2
Recommended products
Rabbit Polyclonal PSTPIP2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PSTPIP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H939
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PSTPIP2 also known as proline-serine-threonine phosphatase-interacting protein 2 is a cytosolic adaptor protein with a mass of approximately 48 kDa. This protein is mainly expressed in immune cells particularly in macrophages. Mechanically PSTPIP2 interacts with phosphatases and plays a role in actin cytoskeleton dynamics. It binds to filamentous actin influencing cell shape and motility. Its interactions with tyrosine phosphatases impact signal transduction processes in the cells where it's expressed.
- Biological function summary
PSTPIP2 acts as a regulatory molecule that influences inflammation and immune responses. It is a component of molecular complexes that mediate cytoskeletal rearrangement. PSTPIP2 modulates signaling pathways that are important for the activation and differentiation of immune cells. It has a role in limiting excessive inflammatory responses serving as a checkpoint in immune cellular functions.
- Pathways
PSTPIP2 is a part of processes involving the regulation of actin dynamics and signal transduction in immune cells. It operates in the Rho GTPase pathway working with proteins like CDC42 which affects cell migration and immune response modulation. PSTPIP2 is also involved in pathways that regulate cytokine signaling influencing inflammatory responses and interacting with several kinases that are essential in this process.
- Associated diseases and disorders
PSTPIP2 has associations with inflammatory conditions such as autoinflammatory diseases. Mutations or dysregulation of this protein link to disorders like chronic recurrent multifocal osteomyelitis. It interacts with proteins involved in inflammation such as the pyrin protein and alterations in PSTPIP2 function can impact the regulatory processes that keep inflammation in balance leading to disease development.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-PSTPIP2 antibody (ab155543)
All lanes: Western blot - Anti-PSTPIP2 antibody (ab155543) at 1/2000 dilution
Lane 1: Raw264.7 whole cell lysate at 20 µg
Lane 2: Raw264.7 knock down PSTPIP2 whole cell lysate at 20 µg
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PSTPIP2 antibody (ab155543)
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, labeling PSTPIP2 with ab155543 at 1/250 dilution.
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