Anti-PTBP2 antibody [EPR9890] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PTBP2 also known as Polypyrimidine Tract Binding Protein 2 or nPTB is an RNA-binding protein with an approximate molecular mass of 57 kDa. It functions mechanically through the regulation of alternative splicing a critical process in the post-transcriptional modification of pre-mRNA. PTBP2 has a prominent presence in neuronal tissues where it influences the maturation and differentiation of neurons by modulating gene expression. It shares structural similarities with its paralog PTBP1 but is expressed particularly in the nervous system.

Biological function summary

PTBP2 influences various neural functions by modulating the splicing of target RNA transcripts. It contributes to the dynamic regulation of splicing events during neurogenesis and neural development forming part of splicing regulatory networks. PTBP2 does not function as part of a larger protein complex but interacts directly with RNA substrates impacting their stability and translation efficiency. This protein is essential for specific splicing events necessary for neurodevelopmental transitions.

Pathways

PTBP2 affects neural development and differentiation through pathways like axon guidance and synaptic transmission. Its role in alternative splicing enables the proper expression of proteins involved in these pathways such as NRG1 and DSCAM. PTBP2 works closely with related splicing proteins and RNA-binding proteins coordinating the production of specific protein isoforms required for neuronal circuit formation and maintenance.

Associated diseases and disorders

PTBP2 has connections with neurodevelopmental conditions such as autism spectrum disorders (ASD) and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). In these contexts abnormal expression or splicing activity of PTBP2 can lead to dysregulation of genes involved in neural connectivity and survival. The interactions between PTBP2 and proteins such as FUS and TDP-43 are significant in understanding its role in neurodegenerative pathways. These associations highlight the importance of precise PTBP2 function in maintaining neural health and function.