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AB121620

Anti-PTCD1 antibody

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(1 Publication)

Rabbit Polyclonal PTCD1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTCD1 aa 400-550.

View Alternative Names

KIAA0632, PTCD1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTCD1 antibody (AB121620)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTCD1 antibody (AB121620)

ab121620 at 1/125 staining PTCD1 in Paraffin Embedded Human placenta tissue by Immunohistochemistry.
Note : strong cytoplasmic positivity in trophoblastic cells.

Western blot - Anti-PTCD1 antibody (AB121620)
  • WB

Unknown

Western blot - Anti-PTCD1 antibody (AB121620)

All lanes:

Western blot - Anti-PTCD1 antibody (ab121620) at 1/250 dilution

Lane 1:

RT4 lysate

Lane 2:

U 251 MG lysate

Lane 3:

Human plasma

Lane 4:

Human Liver lysate

Lane 5:

Human Tonsil lysate

Predicted band size: 79 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTCD1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

O75127

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTCD1 also known as Pentatricopeptide Repeat Domain 1 is a mitochondrial protein involved in RNA processing. This protein has an approximate mass of 64 kDa. It is expressed in various tissues with significant levels found in the heart and skeletal muscles. PTCD1 is located within the mitochondria where it performs its mechanical functions related to RNA metabolism.
Biological function summary

PTCD1 participates in the stability and processing of mitochondrial RNA. It is an essential component of mitochondrial RNA metabolism interacting with RNA molecules to facilitate proper mitochondrial gene expression. PTCD1 does not appear to be part of a larger complex but it performs critical individual functions within the mitochondrial matrix.

Pathways

The protein PTCD1 plays a part in the mitochondrial gene expression pathway. It manages the processing and stability of mitochondrial mRNA which is necessary for the translation of mitochondrial protein-coding genes. PTCD1 is closely related to other mitochondrial RNA-binding proteins such as LRPPRC which also have roles in mRNA stability and expression.

PTCD1 has been connected to mitochondrial disorders particularly those linked with mitochondrial RNA processing defects. Its improper function can lead to mitochondrial myopathies which are disorders that affect muscle function due to mitochondrial dysfunction. PTCD1's role is important in understanding these conditions especially in relation to LRPPRC which shares overlapping functions in mitochondrial RNA metabolism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs.
See full target information PTCD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed36446521

2022

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Flavia Roşianu,Simeon R Mihaylov,Noreen Eder,Antonie Martiniuc,Suzanne Claxton,Helen R Flynn,Shamsinar Jalal,Marie-Charlotte Domart,Lucy Collinson,Mark Skehel,Ambrosius P Snijders,Matthias Krause,Sharon A Tooze,Sila K Ultanir
View all publications
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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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