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AB237019

Anti-PTDSS1 antibody

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(2 Publications)

Rabbit Polyclonal PTDSS1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTDSS1 aa 1-50.

View Alternative Names

KIAA0024, PSSA, PTDSS1, Phosphatidylserine synthase 1, PSS-1, PtdSer synthase 1, Serine-exchange enzyme I

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTDSS1 antibody (AB237019)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTDSS1 antibody (AB237019)

Immunohistochemical analysis of ab237019 diluted at 1 : 150 and staining in paraffin-embedded humanpancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labelled by HRP and visualized using 0.05% DAB. Secondary antibody only control : uses 1% BSA instead of primary antibody

Western blot - Anti-PTDSS1 antibody (AB237019)
  • WB

Supplier Data

Western blot - Anti-PTDSS1 antibody (AB237019)

All lanes:

Western blot - Anti-PTDSS1 antibody (ab237019) at 1/1000 dilution

Lane 1:

293T whole cell lysate at 20 µg

Lane 2:

K562 whole cell lysate at 20 µg

Lane 3:

HepG2 whole cell lysate at 20 µg

Lane 4:

MCF7 whole cell lysate at 20 µg

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/20000 dilution

Observed band size: 35 kDa

false

Exposure time: 60s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTDSS1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P48651

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTDSS1 also known as phosphatidylserine synthase 1 catalyzes the conversion of phosphatidylcholine to phosphatidylserine. This enzyme has a molecular mass of approximately 55 kDa and predominantly resides in the endoplasmic reticulum. It plays a role in lipid metabolism and is expressed in various tissues but is particularly active in the brain and liver. The activity of PTDSS1 is essential for maintaining the balance between different phospholipids in cellular membranes.
Biological function summary

Phosphatidylserine synthase 1 contributes to the production of phosphatidylserine an important phospholipid found in cell membranes and involved in cell signaling and apoptosis. PTDSS1 is not part of any known complex but regulates phosphatidylserine levels that aid in cellular functions such as lipid signaling and membrane structure. This regulation is essential as disruptions can influence cell function and viability.

Pathways

PTDSS1 is involved in the phospholipid biosynthesis pathway which is important for maintaining the function of cellular membranes. It influences pathways associated with cell survival and apoptosis due to its role in balancing phospholipid composition. PTDSS1 interplays with other proteins in these pathways including kinases and phosphatases which modulate cell signaling and membrane dynamics.

PTDSS1 alterations have connections to conditions such as neurological disorders and metabolic syndromes. Disruption in phosphatidylserine levels can contribute to neurodegenerative diseases where PTDSS1 interacts with proteins involved in cell death and survival pathways. Additionally abnormalities in PTDSS1 expression or function might link to metabolic disorders affecting lipid metabolism and cellular energy balance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed : 19014349, PubMed : 24241535). Catalyzes mainly the conversion of phosphatidylcholine (PubMed : 19014349, PubMed : 24241535). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed : 19014349, PubMed : 24241535).
See full target information PTDSS1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 44:280 PubMed41053860

2025

Peripheral nerve injury-induced remodeling of the tumor-associated macrophages promotes immune evasion in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yongxue Jiang,Wenfeng Zeng,Yaxin Feng,Xiaoting Deng,Jiayi Wang,Haiyu Liu,Boying Gao,Dexi Bi,Zifei Liu,Chaoqun Yang,Minxia Chen,Tang Li,Houying Chen,Yuxi Zhang,Luyuan Liang,Jiannan Xu,Wen Deng,Zeyu Yao,Wei Wu,Liyan Lao,Jianing Chen,Penghan Huang

Discover. Oncology 14:188 PubMed37874388

2023

A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation.

Applications

Unspecified application

Species

Unspecified reactive species

Yangyang Lei,Boxuan Zhou,Xiangzhi Meng,Mei Liang,Weijian Song,Yicheng Liang,Yushun Gao,Minghui Wang
View all publications
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Product promise

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