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AB245889

Anti-PTF1A antibody

4

(1 Review)

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(0 Publication)

Goat Polyclonal PTF1A antibody. Suitable for IHC-Fr and reacts with Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Mouse Ptf1a aa 1-250.

View Alternative Names

Ptf1p48, Ptf1a, Pancreas transcription factor 1 subunit alpha, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-Fr

applications

Immunogen

Recombinant Fragment Protein within Mouse Ptf1a aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9QX98

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/5000", "IHCFr-species-notes": "<p></p>" }, "Rat": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTF1A also known as pancreas specific transcription factor 1a or PTFL is a bHLH (basic Helix-Loop-Helix) transcription factor with a mass of approximately 35 kDa. This protein functions as a DNA-binding protein that regulates gene expression. It is mainly expressed in the pancreas especially within pancreatic progenitor cells and also in certain neural tissues. PTF1A is necessary for the transcriptional activity of genes involved in pancreatic development.
Biological function summary

The PTF1A protein plays a significant role in pancreas development and maintenance. It forms a complex as part of the pancreas transcription factor 1 (PTF1) complex which includes other proteins like RBPJL and the E-box binding protein. This complex binds to specific regulatory regions of DNA to modulate the expression of genes important for acinar cell differentiation and function in the pancreas.

Pathways

PTF1A operates within the Notch signaling pathway and the Wnt signaling pathway. In the Notch pathway PTF1A interacts with proteins such as Notch receptors and target HES genes to influence cell differentiation. Within the Wnt pathway PTF1A impacts genes involved with cell fate decisions during pancreatic development working with signaling proteins like beta-catenin to mediate its effects.

PTF1A mutations are associated with pancreatic agenesis and cerebellar atrophy. Pancreatic agenesis involves the underdevelopment or absence of the pancreas resulting in glucose homeostasis complications. PTF1A can interact with genes such as PDX1 in this context which is another transcription factor involved in pancreatic development. In cerebellar atrophy the disruptions in PTF1A expression can lead to problems with cerebellar development causing neurological symptoms due to its interaction with neural development pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
See full target information Ptf1a
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB182398

Anti-PTF1A antibody [EPR19011]

primary-antibodies

ptf1a-antibody-epr19011-ab182398

3

(1 reviews)

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