Anti-PTGER3 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PTGER3 involves itself in mediating the effects of prostaglandin E2 through the inhibition of adenylate cyclase and the modulation of intracellular calcium levels. It does not operate as part of a larger protein complex but functions independently as a receptor. This receptor's activity influences processes such as smooth muscle contraction regulation of body temperature and modulation of hormone release. The variation in signaling allows PTGER3 to have a broad impact on physiological processes adapting its functions based on tissue and cellular context.

Pathways

PTGER3 is part of the prostaglandin signaling pathway and participates in cAMP signaling. It interacts with G-proteins that act as intermediates to modulate adenylate cyclase activity and control cyclic AMP production. The receptor acts in a network with other prostaglandin receptors such as PTGER1 PTGER2 and PTGER4 coordinating responses to PGE2 by either amplifying or opposing their effects depending on the cellular environment. Such interactions position PTGER3 at the junction of pathways critical for homeostatic control and adaptive responses.