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Rabbit Polyclonal PTGFRN antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Prostaglandin F2 receptor negative regulator aa 350-500.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (AB224392), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Prostaglandin F2 receptor negative regulator aa 350-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2B2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/20.00000 - 1/50.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Associated Products

Select an associated product type

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Target data

Function

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal PTGFRN antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Prostaglandin F2 receptor negative regulator aa 350-500.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Prostaglandin F2 receptor negative regulator aa 350-500. The exact immunogen used to generate this antibody is proprietary information. Database link Q9P2B2
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PTGFRN also known as Prostaglandin F2 receptor negative regulator is a membrane protein with a mass of approximately 94 kDa. This protein is expressed on various cell types including immune cells like monocytes and macrophages as well as in the heart and lung tissues. PTGFRN interacts with other membrane proteins to modify signalling pathways particularly those involving G-protein-coupled receptors.

Biological function summary

PTGFRN modulates prostaglandin-mediated signaling serving as a regulatory component that dampens the response to prostaglandin F2 alpha. It is part of a multi-protein complex which includes interactions with proteins like CD9 and integrins. These interactions influence cell adhesion and mobility making PTGFRN relevant in processes like inflammation and tissue repair.

Pathways

PTGFRN plays a significant role in the prostaglandin signaling cascade affecting signal transduction linked with inflammatory responses. It is closely associated with the PI3K/Akt pathway a critical pathway for cellular survival and proliferation. The interactions between PTGFRN and CD9 or integrins facilitate the integration of signals that modify cell growth and immune function.

Associated diseases and disorders

PTGFRN has been implicated in heart failure and inflammatory lung diseases like chronic obstructive pulmonary disease (COPD). In heart failure PTGFRN can interact with integrins to influence cardiac remodeling and fibrosis. In COPD its regulatory function within the prostaglandin pathway affects inflammatory responses. Understanding these interactions provides insights into potential therapeutic targets for managing these conditions.

Product promise

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3 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392)

    Immunohistochemical analysis of human endometrium tissue labeling PTGFRN with ab224392 at 1/20 dilution. Strong membranous positivity in glandular cells.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392)

    Immunohistochemical analysis of human prostate tissue labeling PTGFRN with ab224392 at 1/20 dilution. Strong membranous positivity in glandular cells.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGFRN antibody (ab224392)

    Immunohistochemical analysis of human endometrium tissue labeling PTGFRN with ab224392 at 1/20 dilution. Moderate membranous and cytoplasmic positivity in glandular cells.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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