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AB222818

Anti-PTGR1 antibody

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(2 Publications)

Rabbit Polyclonal PTGR1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTGR1 aa 200-300.

View Alternative Names

LTB4DH, PTGR1, Prostaglandin reductase 1, PRG-1, 15-oxoprostaglandin 13-reductase, Dithiolethione-inducible gene 1 protein, Leukotriene B4 12-hydroxydehydrogenase, NAD(P)H-dependent alkenal/one oxidoreductase, D3T-inducible gene 1 protein, DIG-1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-PTGR1 antibody (AB222818)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PTGR1 antibody (AB222818)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for PTGR1 (green) using ab222818 at 1/100 dilution in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR1 antibody (AB222818)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR1 antibody (AB222818)

Paraffin-embedded human liver tissue stained for PTGR1 using ab222818 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PTGR1 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q14914

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
>95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTGR1 also known as Prostaglandin Reductase 1 acts as an enzyme within cellular metabolism. It functions by catalyzing the reduction of prostaglandins namely converting 15-keto-prostaglandins to their respective 1314-dihydro metabolites. PTGR1 has a molecular mass of approximately 35 kDa. This enzyme primarily expresses in liver tissues but it is present in other tissues like the lungs and kidneys as well.
Biological function summary

PTGR1 participates in metabolizing prostaglandins which play important roles in inflammation and homeostasis. It does not form part of a larger protein complex but works independently to control the levels of active prostaglandins within cells. This activity regulates physiological processes such as inflammation and vascular tone.

Pathways

Prostaglandin metabolism involves PTGR1's function. It integrates into the arachidonic acid pathway. Within this pathway PTGR1 interacts with other enzymes such as cyclooxygenases and lipoxygenases orchestrating the catabolism of prostaglandins and related lipid compounds. This coordination maintains the balance of inflammatory responses.

PTGR1 contributes significantly to inflammatory conditions and cancer. Elevated or altered PTGR1 activity associates with various inflammatory diseases due to its role in prostaglandin catabolism. Additionally in some cancer types abnormal prostaglandin levels mediated by PTGR1 affect tumor growth. The enzyme's participation in these processes links it to proteins such as COX-2 which is critical for prostaglandin synthesis and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids : prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed : 25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed : 25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed : 25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed : 25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
See full target information PTGR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:27448 PubMed39523403

2024

Assessing expression patterns of PTGR1, a potential biomarker for acylfulven sensitivity in urothelial carcinoma.

Applications

IHC-P

Species

Human

Dag Rune Stormoen,Signe Lehn,Kent W Mouw,Zoltan Szallasi,Linea Cecilie Melchior,Line Hammer Dohn,Judit Börcsok,Maria Rossing,Birgitte Grønkaer Toft,Helle Pappot

Cell death & disease 14:248 PubMed37024473

2023

Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Ángel Gaudioso,Xuntian Jiang,Josefina Casas,Edward H Schuchman,María Dolores Ledesma
View all publications
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Alternative Products

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Complementary Products

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Secondary Antibodies

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Cell Lines & Lysates

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Cell Lines & Lysates

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Advanced Validation

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