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AB236891

Anti-PTGR2 antibody

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(1 Publication)

Rabbit Polyclonal PTGR2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTGR2 aa 200-300.

View Alternative Names

ZADH1, PTGR2, Prostaglandin reductase 2, PRG-2, 15-oxoprostaglandin 13-reductase, Zinc-binding alcohol dehydrogenase domain-containing protein 1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR2 antibody (AB236891)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR2 antibody (AB236891)

Paraffin-embedded human testis tissue stained for PTGR2 using ab236891 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR2 antibody (AB236891)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTGR2 antibody (AB236891)

Paraffin-embedded human kidney tissue stained for PTGR2 using ab236891 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-PTGR2 antibody (AB236891)
  • WB

Supplier Data

Western blot - Anti-PTGR2 antibody (AB236891)

All lanes:

Western blot - Anti-PTGR2 antibody (ab236891) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTGR2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q8N8N7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTGR2 also known as Prostaglandin Reductase 2 is an enzyme with a molecular weight of approximately 37 kDa. The enzyme catalyzes the reduction of 15-keto prostaglandins into more inactive forms. PTGR2 is widely expressed in various tissues with higher levels observed in the liver and kidney. Its function involves balancing the levels of prostaglandins which are important lipid compounds in the human body.
Biological function summary

PTGR2 plays a significant role in modulating inflammatory responses and cellular processes by regulating prostaglandin metabolism. The enzyme does not function as part of a larger protein complex acting independently to convert active prostaglandins into their less active forms. By doing so PTGR2 indirectly influences inflammation and other cellular responses triggered by prostaglandins.

Pathways

This enzyme contributes significantly to prostaglandin metabolic pathways. PTGR2's activity impacts the cycle involving oxidative degradation of prostaglandins which in turns affect inflammation and immune system responses. It works alongside proteins such as PTGR1 and enzymes linked with arachidonic acid metabolism essential in prostaglandin biosynthesis and degradation pathways.

PTGR2 implicates itself in conditions related to inflammation and cancer. Increased activity of PTGR2 has been linked to the progression of certain cancers such as colorectal cancer due to its role in altering local concentrations of prostaglandins that influence tumor growth. PTGR2's regulation of prostaglandins also associates it with inflammatory diseases as abnormal prostaglandin levels can exacerbate these conditions. Connections with proteins like COX-2 emphasize its significance in these diseases as COX-2 plays a pivotal role in prostaglandin synthesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed : 19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
See full target information PTGR2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:5331 PubMed38909026

2024

TENT5-mediated polyadenylation of mRNAs encoding secreted proteins is essential for gametogenesis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Michał Brouze,Agnieszka Czarnocka-Cieciura,Olga Gewartowska,Monika Kusio-Kobiałka,Kamil Jachacy,Marcin Szpila,Bartosz Tarkowski,Jakub Gruchota,Paweł Krawczyk,Seweryn Mroczek,Ewa Borsuk,Andrzej Dziembowski
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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