AB79539

Anti-PTHLH antibody [3D1.1]

Name: Anti-PTHLH antibody [3D1.1] (ab79539) | Abcam
Brand: Abcam Limited
SKU: AB79539
Price: 495 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal PTHLH antibody. Suitable for Flow Cyt, ELISA, WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PTHLH aa 100-200.

View Alternative Names

PTHRP, PTHLH, Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

3D1.1

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt, IHC-P, ELISA, WB

applications

Immunogen

Synthetic Peptide within Human PTHLH aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

P12272

Specificity

This clone reacts with the human Type I hPTH/PTHrP and it does not react with the Type II receptor.

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parathyroid hormone-like hormone (PTHLH) also known as PTHrP is a protein made by the PTHLH gene. It weighs around 17 kDa and its expression occurs in many tissues including the bone skin and developing structures during embryogenesis. PTHLH interacts with parathyroid hormone receptors offering actions similar to parathyroid hormone (PTH). This interaction helps to extend its role beyond classical calcium homeostasis to include other functions such as growth and developmental processes.

Biological function summary

PTHLH plays a role in cartilage development and endochondral bone formation. It functions as a significant regulator of cellular proliferation and differentiation especially in chondrocytes and osteoblasts. PTHLH can also act as part of multiprotein complexes that influence transcription and intracellular signaling. Furthermore it possesses diverse roles including smooth muscle contraction mammary gland development and cellular differentiation inhibition.

Pathways

Alongside related proteins like Indian Hedgehog (IHH) PTHLH resides in pathways critical for skeletal development and homeostasis. Notably the PTHLH/PTHR1 signaling pathway regulates chondrocyte maturation during bone growth. This pathway intersects with the Hedgehog pathway to form a regulatory loop essential for maintaining the growth plate's development and maturation. PTHLH also influences the Wnt signaling pathway associated with bone density and health.

PTHLH has connections with certain cancers specifically breast cancer and hypercalcemia of malignancy. In cancerous tissues PTHLH can be overexpressed leading to increased osteoclastic bone resorption contributing to cancer-associated conditions. Additionally PTHLH overactivity links it to familial benign hypercalcemia through its interactions with PTH and its receptors. Understanding these associations could offer therapeutic targets for treatment.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed : 12538599, PubMed : 35932760, PubMed : 3616618). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed : 19674967, PubMed : 35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed : 12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed : 12538599). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (By similarity). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 (PubMed : 20637541).. Osteostatin. Potent inhibitor of osteoclastic bone resorption.

See full target information PTHLH

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 11:4113-4116 PubMed27313750

2016

An unusual mediastinal parathyroid carcinoma coproducing PTH and PTHrP: A case report.

Applications

Unspecified application

Species

Unspecified reactive species

Chuangjie Cao,Chengyun Dou,Fuqin Chen,Yan Wang,Xiaoli Zhang,Hong Lai

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PTHLH antibody [3D1.1]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise