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AB134803

Anti-PTMA antibody

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(1 Publication)

Goat Polyclonal PTMA antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PTMA aa 50 to C-terminus.

View Alternative Names

TMSA, PTMA, Prothymosin alpha

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTMA antibody (AB134803)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTMA antibody (AB134803)

Immunohistochemistry analysis of Formalin fixed and Paraffin Embedded (IHC-P) Human Spleen tissue labelling PTMA with ab134803 at 3.75 µg/ml.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PTMA aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P06454

Specificity

This antibody is expected to recognize both reported isoforms (NP_001092755.1; NP_002814.3).

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Goat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prothymosin alpha (PTMA) also known as prothymosin is a small nuclear protein characterized by a polypeptide chain with a molecular mass of approximately 12 kDa. PTMA is broadly expressed across various tissues with abundant levels in the thymus and spleen. Its sequence is rich in acidic amino acids a feature that influences its interaction with other biomolecules. Prothymosin alpha undergoes post-translational modifications further affecting its functions within the cell.
Biological function summary

Prothymosin alpha plays a role in chromatin remodeling and regulation of gene expression. It acts as part of the chromatin-modifying complex interacting with other proteins to influence transcription processes. PTMA contributes to cell proliferation and apoptosis aiding cellular defense mechanisms. Its presence in the nucleus is significant for the cell cycle where it regulates the transition between phases.

Pathways

PTMA participates in the apoptotic pathways and the regulation of gene transcription. It works closely with proteins such as histone acetyltransferase complexes which are important for modifying chromatin structure and facilitating transcription. Prothymosin alpha interacts with apoptosis regulatory proteins impacting how cells respond to apoptotic signals and controlling cellular growth and death.

PTMA has connections with cancer and autoimmune diseases. Its involvement in cell proliferation links it to oncogenesis where overexpression of PTMA has been observed. The protein also interfaces with immune regulatory proteins influencing autoimmune conditions. PTMA’s dysregulation can induce abnormal cell cycle progression contributing to disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
See full target information PTMA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Bio-protocol 7:e2131 PubMed34458452

2017

Analysis of Cancer Stromal Reaction Using an O-ring Co-culture Assay.

Applications

Unspecified application

Species

Unspecified reactive species

Vivien Jane Coulson-Thomas
View all publications
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Product promise

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