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AB247074

Anti-PTMA antibody

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(5 Publications)

Rabbit Polyclonal PTMA antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTMA aa 1-100.

View Alternative Names

TMSA, PTMA, Prothymosin alpha

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTMA antibody (AB247074)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTMA antibody (AB247074)

Paraffin-embedded human duodenum tissue stained for PTMA using ab247074 at 1/20 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PTMA antibody (AB247074)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PTMA antibody (AB247074)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for PTMA (green) using ab247074 at 4 μg/ml in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PTMA aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P06454

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prothymosin alpha (PTMA) also known as prothymosin is a small nuclear protein characterized by a polypeptide chain with a molecular mass of approximately 12 kDa. PTMA is broadly expressed across various tissues with abundant levels in the thymus and spleen. Its sequence is rich in acidic amino acids a feature that influences its interaction with other biomolecules. Prothymosin alpha undergoes post-translational modifications further affecting its functions within the cell.
Biological function summary

Prothymosin alpha plays a role in chromatin remodeling and regulation of gene expression. It acts as part of the chromatin-modifying complex interacting with other proteins to influence transcription processes. PTMA contributes to cell proliferation and apoptosis aiding cellular defense mechanisms. Its presence in the nucleus is significant for the cell cycle where it regulates the transition between phases.

Pathways

PTMA participates in the apoptotic pathways and the regulation of gene transcription. It works closely with proteins such as histone acetyltransferase complexes which are important for modifying chromatin structure and facilitating transcription. Prothymosin alpha interacts with apoptosis regulatory proteins impacting how cells respond to apoptotic signals and controlling cellular growth and death.

PTMA has connections with cancer and autoimmune diseases. Its involvement in cell proliferation links it to oncogenesis where overexpression of PTMA has been observed. The protein also interfaces with immune regulatory proteins influencing autoimmune conditions. PTMA’s dysregulation can induce abnormal cell cycle progression contributing to disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
See full target information PTMA
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8295 PubMed40957887

2025

A mesothelial differentiation gateway drives fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Safwen Kadri,Adrian Fischer,Martin Mück-Häusl,Wei Han,Amal Kadri,Yue Lin,Lin Yang,Shaoping Hu,Haifeng Ye,Pushkar Ramesh,Meshal Ansari,Herbert B Schiller,Hans-Günther Machens,Yuval Rinkevich

BMC cancer 24:93 PubMed38233795

2024

UTP11 promotes the growth of hepatocellular carcinoma by enhancing the mRNA stability of Oct4.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Chen,Xiaowei Zhang,Mingcheng Zhang,Wenting Fan,Yueyue Lin,Guodong Li

Communications biology 5:1322 PubMed36460747

2022

Protein structure determination in human cells by in-cell NMR and a reporter system to optimize protein delivery or transexpression.

Applications

Unspecified application

Species

Unspecified reactive species

Juan A Gerez,Natalia C Prymaczok,Harindranath Kadavath,Dhiman Ghosh,Matthias Bütikofer,Yanick Fleischmann,Peter Güntert,Roland Riek

Biomolecules 12: PubMed36139050

2022

First Evidence of the Expression and Localization of Prothymosin α in Human Testis and Its Involvement in Testicular Cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Massimo Venditti,Davide Arcaniolo,Marco De Sio,Sergio Minucci

International journal of molecular sciences 23: PubMed35563519

2022

New Insight on the In Vitro Effects of Melatonin in Preserving Human Sperm Quality.

Applications

Unspecified application

Species

Unspecified reactive species

Sergio Minucci,Massimo Venditti
View all publications
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Product promise

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