AB169769

Anti-PTP alpha (phospho Y798) antibody [EPR10369]

RabMAb
Recombinant
What is this?

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Recombinant Monoclonal PTP alpha phospho Y798 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications.

View Alternative Names

PTPA, PTPRL2, PTPRA, Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha

1 Images

Unknown

Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (AB169769)

All lanes:

Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (ab169769) at 1/1000 dilution

Lane 1:

C6 cell lysate, untreated at 10 µg

Lane 2:

C6 cell lysate, treated with AP at 10 µg

Secondary

All lanes:

HRP labeled goat anti-rabbit at 1/2000 dilution

Predicted band size: 91 kDa

false

Carrier free

Anti-PTP alpha (phospho Y798) antibody [EPR10369] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10369

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Conditional Ambient

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein Tyrosine Phosphatase Alpha (PTP alpha) also known as PTPRA serves as an enzyme that removes phosphate groups from specific tyrosine residues on proteins. It has an approximate molecular weight of 130 kDa. PTP alpha is located in the cell membrane and shows expression in various tissues including the brain liver and skeletal muscle. It functions as a signaling molecule that modifies the activity of several proteins playing a significant role in cell growth differentiation and mitosis.

Biological function summary

PTPRA influences cellular processes by serving as a regulator of the Src family of tyrosine kinases which are important for intracellular signal transduction. PTP alpha does not form part of a complex but rather exists as a monomer although it can interact with other proteins. Its activity helps maintain the balance of phosphorylation and dephosphorylation which is essential for cellular signaling homeostasis.

Pathways

PTP alpha acts in the integrin and growth factor receptor signaling pathways. It plays a role in integrin signaling by dephosphorylating substrates that modulate cell adhesion and migration. Additionally in growth factor receptor signaling PTP alpha modulates cell proliferation by interacting with substrates such as the epidermal growth factor receptor (EGFR). It shares pathway links with proteins like SRC and FAK emphasizing its regulatory role over them.

PTP alpha has associations with cancer particularly in cases such as colorectal and breast cancer. It affects cancer progression by modifying signaling involved in uncontrolled cell growth. Furthermore PTPRA has findings connecting it with neurodegenerative diseases like Alzheimer's through its effect on signaling cascades that involve amyloid precursor protein (APP). In these contexts PTP alpha’s interactions with proteins such as EGFR and FAK reveal its significance in disease pathology.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

See full target information PTPRA pY798

style

left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed34439388

2021

Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyan Wu,Li Wang,Nicole A Pearson,Santosh Renuse,Ran Cheng,Ye Liang,Dong-Gi Mun,Anil K Madugundu,Yaoyu Xu,Parkash S Gill,Akhilesh Pandey

Chinese medicine 16:66 PubMed34321072

2021

Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.

Applications

Unspecified application

Species

Unspecified reactive species

Yanfang Peng,Yingwen Zhang,Yabing Zhang,Xiuping Wang,Yukun Xia

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PTP alpha (phospho Y798) antibody [EPR10369]

Western blot - Anti-PTP alpha (phospho Y798) antibody [EPR10369] (AB169769)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise