Rabbit Polyclonal PTP zeta/ Phosphacan antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPRZ1 aa 800-1000.
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Publications
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- Advanced healthcare materials 11:e22015862022Tissue Niche Miniature of Glioblastoma Patient Treated with Nano-Awakeners to Induce Suicide of Cancer Stem Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeon-Jin Yoon,Sewoom Baek,Seung Eun Yu,Euna Jo,Dongkyu Lee,Jin-Kyoung Shim,Ran Joo Choi,Junseong Park,Ju Hyung Moon,Eui-Hyun Kim,Jong Hee Chang,Jung Bok Lee,Joon-Sang Park,Hak-Joon Sung,Seok-Gu KangPubMed 36047642
- Nature communications 10:27802019Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesT Kawaue et. al.PubMed 31239441
- Cell communication and signaling : CCS 16:922018Chemotherapy-driven increases in the CDKN1A/PTN/PTPRZ1 axis promote chemoresistance by activating the NF-κB pathway in breast cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeng Huang et. al.PubMed 30497491
- Cell reports 21:3970-39862017Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesScott A Yuzwa,Michael J Borrett,Brendan T Innes,Anastassia Voronova,Troy Ketela,David R Kaplan,Gary D Bader,Freda D MillerPubMed 29281841
- The Journal of clinical investigation 125:3198-2142015IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJea-Hyun Baek et. al.PubMed 26121749
- Schizophrenia research 150:366-722013Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PTPRZ1 aa 800-1000. The exact immunogen used to generate this antibody is proprietary information. Database link P23471
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-4.00000 µg/mL | Notes Recommend PFA Fixation and Triton X-100 treatment |
Associated Products
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Target data
Function
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
Alternative names
HTPZP2, PTPRZ, PTPRZ2, PTPZ, PTPRZ1, Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2
Recommended products
Rabbit Polyclonal PTP zeta/ Phosphacan antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPRZ1 aa 800-1000.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PTPRZ1 aa 800-1000. The exact immunogen used to generate this antibody is proprietary information. Database link P23471
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PTP zeta also known as Phosphacan is a protein tyrosine phosphatase expressed mainly in the central nervous system. It is a chondroitin sulfate proteoglycan with a molecular weight of approximately 340 kDa. This protein is found on neuronal and glial cell surfaces. PTP zeta plays a role in cell signaling by dephosphorylating specific tyrosine residues on target proteins. Its interaction with ECM molecules and receptors supports cell-cell communication and structural organization within neural tissues.
- Biological function summary
In development and recovery of nervous system components PTP zeta plays key roles. It engages in signaling networks that regulate cell adhesion migration and proliferation. Phosphacan shares structures with other receptor-like proteins and interfaces with various ligands indicating its involvement in complex multi-protein assemblies. Interaction with growth factors such as pleiotrophin influences neural cell differentiation and axonal growth.
- Pathways
PTP zeta integrates into signaling processes controlling neural plasticity and regeneration. It participates in the PI3K/Akt pathway where it modifies cell survival and growth dynamics. The protein also associates with the MAPK/ERK pathway impacting neuronal differentiation and proliferation. Here it interacts with other proteins like fibroblast growth factor (FGF) enhancing its regulatory influence on cellular functions critical to the CNS.
- Associated diseases and disorders
PTP zeta has connections with conditions like glioblastoma and schizophrenia. Altered expression levels associate it with these pathologies as it significantly influences cell proliferation and migration patterns that could contribute to tumor growth or neurodevelopmental anomalies. PTP zeta interacts with integrin proteins which are implicated in mediating these disease mechanisms through their role in ECM and cell cytoskeleton interactions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTP zeta/ Phosphacan antibody (ab126497)
ab126497 at 1/50 dilution staining PTP zeta/ Phosphacan in paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry.
Western blot - Anti-PTP zeta/ Phosphacan antibody (ab126497)
All lanes: Western blot - Anti-PTP zeta/ Phosphacan antibody (ab126497)
All lanes: Human brain tissue
Predicted band size: 255 kDa
Immunocytochemistry/ Immunofluorescence - Anti-PTP zeta/ Phosphacan antibody (ab126497)
Immunofluorescent staining of Human cell line A-431 shows positivity in vesicles. Recommended concentration of ab126497 1-4 µg/ml. Cells treated with PFA/Triton X-100.
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