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Mouse Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus.

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Images

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776), expandable thumbnail
  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776), expandable thumbnail

Publications

Key facts

Isotype
IgG2b
Host species
Mouse
Storage buffer

Preservative: 0.05% Sodium azide
Constituents: 99% PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12974

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/2000.00000
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Alternative names

PRL2, PTPCAAX2, BM-008, PTP4A2, Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2

Recommended products

Mouse Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus.

Key facts

Isotype
IgG2b
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12974
Clone number
5B6F4
Purification technique
Affinity purification Protein G
Concentration
Loading...
Purification notes

Purified from tissue culture supernatant.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

PTP4A2 also known as PRL2 is a protein tyrosine phosphatase with a mass of approximately 19 kDa. It functions by catalyzing the removal of phosphate groups from tyrosine residues on proteins which regulates various cellular processes. PTP4A2 is expressed in a range of tissues including the liver brain and heart. Its expression has been noted to increase in certain types of cancer suggesting its involvement in tumorigenesis.

Biological function summary

PTP4A2 regulates cell growth migration and invasion. It participates in several biological processes by modulating signaling pathways that control these activities. PTP4A2 does not traditionally form part of a larger protein complex but interacts with other proteins to exert its effects. It is important in normal cellular proliferation and differentiation.

Pathways

PTP4A2 plays a role in the MAPK signaling pathway and interacts with proteins such as ERK1 and ERK2. It is also involved in the PI3K/AKT pathway affecting cell survival and metabolism. Through these pathways PTP4A2 modulates various cellular responses influencing both normal physiological processes and pathological conditions.

Associated diseases and disorders

PTP4A2 shows a significant link to cancer particularly breast and prostate cancers. This protein influences disease progression via alterations in related signaling pathways. PTP4A2 connections to oncogenes like c-Myc highlight its role in tumor development and progression. Its activity in these contexts makes it a potential therapeutic target for cancer treatment strategies.

Product promise

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2 product images

  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776), expandable thumbnail

    Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776)

    All lanes: Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

    All lanes: Human PTP4A2/PRL2 recombinant protein

    Predicted band size: 136 kDa, 19 kDa, 21 kDa, 38 kDa, 41 kDa, 46 kDa, 49 kDa, 52 kDa, 96 kDa

  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776), expandable thumbnail

    Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776)

    All lanes: Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

    Lane 1: HEK293 cell lysate, non-transfected

    Lane 2: HEK293 cell lysate, transfected with PTP4A2/PRL2 (amino acids 58-162)-hIgGFc

    Predicted band size: 19 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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