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AB181776

Anti-PTP4A2/PRL2 antibody [5B6F4]

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(2 Publications)

Mouse Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus.

View Alternative Names

PRL2, PTPCAAX2, BM-008, PTP4A2, Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2

2 Images
Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776)
  • WB

Supplier Data

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776)

All lanes:

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

Lane 1:

HEK293 cell lysate, non-transfected

Lane 2:

HEK293 cell lysate, transfected with PTP4A2/PRL2 (amino acids 58-162)-hIgGFc

Predicted band size: 19 kDa

false

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776)
  • WB

Supplier Data

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776)

All lanes:

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

All lanes:

Human PTP4A2/PRL2 recombinant protein

Predicted band size: 136 kDa,19 kDa,21 kDa,38 kDa,41 kDa,46 kDa,49 kDa,52 kDa,96 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

5B6F4

Isotype

IgG2b

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q12974

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTP4A2 also known as PRL2 is a protein tyrosine phosphatase with a mass of approximately 19 kDa. It functions by catalyzing the removal of phosphate groups from tyrosine residues on proteins which regulates various cellular processes. PTP4A2 is expressed in a range of tissues including the liver brain and heart. Its expression has been noted to increase in certain types of cancer suggesting its involvement in tumorigenesis.
Biological function summary

PTP4A2 regulates cell growth migration and invasion. It participates in several biological processes by modulating signaling pathways that control these activities. PTP4A2 does not traditionally form part of a larger protein complex but interacts with other proteins to exert its effects. It is important in normal cellular proliferation and differentiation.

Pathways

PTP4A2 plays a role in the MAPK signaling pathway and interacts with proteins such as ERK1 and ERK2. It is also involved in the PI3K/AKT pathway affecting cell survival and metabolism. Through these pathways PTP4A2 modulates various cellular responses influencing both normal physiological processes and pathological conditions.

PTP4A2 shows a significant link to cancer particularly breast and prostate cancers. This protein influences disease progression via alterations in related signaling pathways. PTP4A2 connections to oncogenes like c-Myc highlight its role in tumor development and progression. Its activity in these contexts makes it a potential therapeutic target for cancer treatment strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
See full target information PTP4A2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 22:32 PubMed39910617

2025

CD22 modulation alleviates amyloid β-induced neuroinflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Dong Mai,Qingqing Zhang,Cheuk Lim Fung,Shui On Leung,Chi Ho Chong

Computational and mathematical methods in medicine 2021:4439505 PubMed34992672

2021

Downregulated Expression of miRNA-130a-5p Aggravates Hepatoma Progression via Targeting PTP4A2.

Applications

Unspecified application

Species

Unspecified reactive species

Longqing Shi,Fengbo Wang,Yue Zhang,Yue Yang,Zheng Qu,Donglin Sun
View all publications
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Product promise

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