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Mouse Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus.

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Images

Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776), expandable thumbnail
  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (AB181776), expandable thumbnail

Publications

Key facts

Isotype

IgG2b

Host species

Mouse

Storage buffer

Preservative: 0.05% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12974

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/2000.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 products for Alternative Product

Target data

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Alternative names

Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2, PRL2, PTP4A2, PTPCAAX2, BM-008

Recommended products

Mouse Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus.

Alternative names

Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2, PRL2, PTP4A2, PTPCAAX2, BM-008

Key facts

Isotype

IgG2b

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Fragment Protein within Human PTP4A2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q12974
Clone number

5B6F4

Purification technique

Affinity purification Protein G

Concentration
Loading...
Purification notes

Purified from tissue culture supernatant.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PTP4A2 also known as PRL2 is a protein tyrosine phosphatase with a mass of approximately 19 kDa. It functions by catalyzing the removal of phosphate groups from tyrosine residues on proteins which regulates various cellular processes. PTP4A2 is expressed in a range of tissues including the liver brain and heart. Its expression has been noted to increase in certain types of cancer suggesting its involvement in tumorigenesis.

Biological function summary

PTP4A2 regulates cell growth migration and invasion. It participates in several biological processes by modulating signaling pathways that control these activities. PTP4A2 does not traditionally form part of a larger protein complex but interacts with other proteins to exert its effects. It is important in normal cellular proliferation and differentiation.

Pathways

PTP4A2 plays a role in the MAPK signaling pathway and interacts with proteins such as ERK1 and ERK2. It is also involved in the PI3K/AKT pathway affecting cell survival and metabolism. Through these pathways PTP4A2 modulates various cellular responses influencing both normal physiological processes and pathological conditions.

Associated diseases and disorders

PTP4A2 shows a significant link to cancer particularly breast and prostate cancers. This protein influences disease progression via alterations in related signaling pathways. PTP4A2 connections to oncogenes like c-Myc highlight its role in tumor development and progression. Its activity in these contexts makes it a potential therapeutic target for cancer treatment strategies.

Product promise

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2 product images

  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776), expandable thumbnail

    Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776)

    All lanes: Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

    All lanes: Human PTP4A2/PRL2 recombinant protein

    Predicted band size: 136 kDa, 19 kDa, 21 kDa, 38 kDa, 41 kDa, 46 kDa, 49 kDa, 52 kDa, 96 kDa

  • Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776), expandable thumbnail

    Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776)

    All lanes: Western blot - Anti-PTP4A2/PRL2 antibody [5B6F4] (ab181776) at 1/500 dilution

    Lane 1: HEK293 cell lysate, non-transfected

    Lane 2: HEK293 cell lysate, transfected with PTP4A2/PRL2 (amino acids 58-162)-hIgGFc

    Predicted band size: 19 kDa

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Product protocols

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