Rabbit Recombinant Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Images
![Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (AB109118), expandable thumbnail](https://content.abcam.com/products/images/ptp4a2-prl2-antibody-epr3800-ab109118--western-blot-img124423.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (AB109118)")
Publications
Filter by
- Computational and mathematical methods in medicine 2021:44395052021Downregulated Expression of miRNA-130a-5p Aggravates Hepatoma Progression via Targeting PTP4A2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLongqing Shi,Fengbo Wang,Yue Zhang,Yue Yang,Zheng Qu,Donglin SunPubMed 34992672
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% PBS, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| ICC/IF | Flow Cyt | WB | IHC-P | |
|---|---|---|---|---|
| Human | Not recommended | Not recommended | Tested | Not recommended |
| Mouse | Not recommended | Not recommended | Predicted | Not recommended |
| Rat | Not recommended | Not recommended | Predicted | Not recommended |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Alternative names
PRL2, PTPCAAX2, BM-008, PTP4A2, Protein tyrosine phosphatase type IVA 2, HU-PP-1, OV-1, PTP(CAAXII), Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2, PRL-2
Recommended products
Rabbit Recombinant Monoclonal PTP4A2/PRL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% PBS, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR3800
- Purification technique
- Affinity purification Protein A
- Specificity
The immunogen used for this product shares 71% identity (78% positives) with PRL-1. Cross-reactivity with this protein has not been confirmed experimentally.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PTP4A2 also known as PRL2 is a protein tyrosine phosphatase with a mass of approximately 19 kDa. It functions by catalyzing the removal of phosphate groups from tyrosine residues on proteins which regulates various cellular processes. PTP4A2 is expressed in a range of tissues including the liver brain and heart. Its expression has been noted to increase in certain types of cancer suggesting its involvement in tumorigenesis.
- Biological function summary
PTP4A2 regulates cell growth migration and invasion. It participates in several biological processes by modulating signaling pathways that control these activities. PTP4A2 does not traditionally form part of a larger protein complex but interacts with other proteins to exert its effects. It is important in normal cellular proliferation and differentiation.
- Pathways
PTP4A2 plays a role in the MAPK signaling pathway and interacts with proteins such as ERK1 and ERK2. It is also involved in the PI3K/AKT pathway affecting cell survival and metabolism. Through these pathways PTP4A2 modulates various cellular responses influencing both normal physiological processes and pathological conditions.
- Associated diseases and disorders
PTP4A2 shows a significant link to cancer particularly breast and prostate cancers. This protein influences disease progression via alterations in related signaling pathways. PTP4A2 connections to oncogenes like c-Myc highlight its role in tumor development and progression. Its activity in these contexts makes it a potential therapeutic target for cancer treatment strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
![Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (ab109118), expandable thumbnail](https://content.abcam.com/products/images/ptp4a2-prl2-antibody-epr3800-ab109118--western-blot-img124423.jpg "Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (ab109118)")
Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (ab109118)
All lanes: Western blot - Anti-PTP4A2/PRL2 antibody [EPR3800] (ab109118) at 1/1000 dilution
Lane 1: SW480 cell lysate at 10 µg
Lane 2: SKBR-3 cell lysate at 10 µg
Lane 3: A549 cell lysate at 10 µg
Lane 4: HeLa cell lysate at 10 µg
Predicted band size: 19 kDa
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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