JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB26947

Anti-PTP4A3/PRL-R antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal PTP4A3/PRL-R antibody. Suitable for WB and reacts with Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PTP4A3.

View Alternative Names

PRL3, PTP4A3, Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PTP4A3.

O75365

style
left-column

Alternative Products

Primary Antibodies

AB50276

Anti-PTP4A3/PRL-R antibody

  • 0
  • 0

Complementary Products

Assay Kits

AB211091

MTT Assay Kit (Cell Proliferation)

Functional Studies - MTT Assay Kit (Cell Proliferation) (AB211091)

  • 5
  • 2
Proteins & Peptides

AB87716

Recombinant Human PTP4A3/PRL-R protein (His tag N-Terminus + His tag N-Terminus)

Western blot - Recombinant Human PTP4A3/PRL-R protein (His tag N-Terminus + His tag N-Terminus) (AB87716)

  • 0
  • 0
Primary Antibodies

AB283654

Anti-CD68 antibody [EPR23917-164]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size|Advanced Validation

Flow Cytometry - Anti-CD68 antibody [EPR23917-164] (AB283654)

  • 5
  • 1
Primary Antibodies

AB9110

Anti-HA tag antibody - ChIP Grade

Immunoprecipitation - Anti-HA tag antibody - ChIP Grade (AB9110)

  • 5
  • 59
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTP4A3 also known as PRL-R is a protein tyrosine phosphatase with a molecular mass of approximately 19 kDa. This protein is expressed in various tissues but has high levels in cancerous cells. It has a role in the dephosphorylation of substrates impacting cell processes like proliferation and motility. PTP4A3 localizes to the cytoplasm and its enzymatic activity can influence cellular dynamics particularly in rapidly dividing cells.
Biological function summary

PTP4A3 affects cellular growth and division as part of the signaling network. It is involved in the intracellular control of the phosphatase complex and regulates other protein interactions. PTP4A3 influences cell migration and invasion particularly through interactions with structural proteins. As a phosphatase it removes phosphate groups influencing the phosphorylation status of other proteins and altering their functions in the signaling pathways.

Pathways

PTP4A3 takes part in processes like the MAPK and PI3K/AKT signaling pathways. These pathways are critical for cell survival proliferation and differentiation. Within these pathways PTP4A3 modulates interactions with proteins like ERK1/2 and AKT which are important components of the pathways. The phosphatase activity facilitates crosstalk and integration of signals maintaining cellular homeostasis.

Aberrant PTP4A3 expression connects to cancer particularly in metastatic progression. Elevated levels of PTP4A3 correlate with aggressive tumor behavior and poor prognosis. In addition PTP4A3 affects chronic inflammatory disorders through its actions on signaling pathways. It impacts epithelial to mesenchymal transition (EMT) processes linking to proteins like MMPs which play a role in cancer metastasis and inflammation.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
See full target information PTP4A3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer research 71:666-74 PubMed21135111

2010

High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients.

Applications

WB

Species

Human

Cécile Laurent,Fabien Valet,Nathalie Planque,Licia Silveri,Selma Maacha,Océane Anezo,Philippe Hupe,Corine Plancher,Cécile Reyes,Benoit Albaud,Audrey Rapinat,David Gentien,Jérôme Couturier,Xavier Sastre-Garau,Laurence Desjardins,Jean-Paul Thiery,Sergio Roman-Roman,Bernard Asselain,Emmanuel Barillot,Sophie Piperno-Neumann,Simon Saule
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com