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AB50276

Anti-PTP4A3/PRL-R antibody

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(15 Publications)

Rabbit Polyclonal PTP4A3/PRL-R antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human PTP4A3 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

PRL3, PTP4A3, Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human PTP4A3 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O75365

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Purification notes
Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins.
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTP4A3 also known as PRL-R is a protein tyrosine phosphatase with a molecular mass of approximately 19 kDa. This protein is expressed in various tissues but has high levels in cancerous cells. It has a role in the dephosphorylation of substrates impacting cell processes like proliferation and motility. PTP4A3 localizes to the cytoplasm and its enzymatic activity can influence cellular dynamics particularly in rapidly dividing cells.
Biological function summary

PTP4A3 affects cellular growth and division as part of the signaling network. It is involved in the intracellular control of the phosphatase complex and regulates other protein interactions. PTP4A3 influences cell migration and invasion particularly through interactions with structural proteins. As a phosphatase it removes phosphate groups influencing the phosphorylation status of other proteins and altering their functions in the signaling pathways.

Pathways

PTP4A3 takes part in processes like the MAPK and PI3K/AKT signaling pathways. These pathways are critical for cell survival proliferation and differentiation. Within these pathways PTP4A3 modulates interactions with proteins like ERK1/2 and AKT which are important components of the pathways. The phosphatase activity facilitates crosstalk and integration of signals maintaining cellular homeostasis.

Aberrant PTP4A3 expression connects to cancer particularly in metastatic progression. Elevated levels of PTP4A3 correlate with aggressive tumor behavior and poor prognosis. In addition PTP4A3 affects chronic inflammatory disorders through its actions on signaling pathways. It impacts epithelial to mesenchymal transition (EMT) processes linking to proteins like MMPs which play a role in cancer metastasis and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
See full target information PTP4A3
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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

PloS one 18:e0292080 PubMed37768948

2023

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.

Applications

Unspecified application

Species

Unspecified reactive species

Marina P Volegova,Cynthia Hermosillo,Jamie H D Cate

PloS one 18:e0285964 PubMed37220097

2023

Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline N Smith,Kyle Kihn,Zachary A Williamson,K Martin Chow,Louis B Hersh,Konstantin V Korotkov,Daniel Deredge,Jessica S Blackburn

Journal of gastrointestinal oncology 14:863-873 PubMed37201051

2023

Phosphatase regenerating liver 3 participates in Integrinβ1/FAK-Src/MAPK signaling pathway and contributes to the regulation of malignant behaviors in hepatocellular carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Guobin Chen,Zhenzhen Zhang,Jinghuan Li,Chao Hu,Dongmei Gao,Jun Chen,Lan Zhang,Xiaoying Xie

Theranostics 10:10345-10359 PubMed32929353

2020

PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK.

Applications

Unspecified application

Species

Unspecified reactive species

Qiming Zhou,Qianlei Zhou,Qinghua Liu,Zhanghai He,Yongcong Yan,Jianhong Lin,Zheng Chen,Chuanchao He,Kai Mao,Jie Wang,Zhenyu Zhou,Zhiyu Xiao,Jianlong Zhang

Medical science monitor : international medical jo 24:8105-8114 PubMed30418964

2018

Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bing-Hui Li,Yang Wang,Chao-Yang Wang,Ming-Juan Zhao,Tong Deng,Xue-Qun Ren

Oncology letters 15:9069-9074 PubMed29805638

2018

PRL-3 promotes gastric cancer peritoneal metastasis via the PI3K/AKT signaling pathway and .

Applications

Unspecified application

Species

Unspecified reactive species

Yang Zhang,Zhengrong Li,Xiaole Fan,Jianbo Xiong,Guoyang Zhang,Xianshi Luo,Kun Li,Zhigang Jie,Yi Cao,Zuoxi Huang,Feng Wu,Lin Xiao,Guangling Duan,Heping Chen

Oncology letters 15:2795-2800 PubMed29435006

2018

PRL-3 promotes breast cancer progression by downregulating p14-mediated p53 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Xie,Hao Wang

International journal of oncology 52:402-412 PubMed29207031

2017

PRL‑3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients.

Applications

Unspecified application

Species

Unspecified reactive species

Donna R Edwards,Krzysztof Moroz,Haitao Zhang,David Mulholland,Asim B Abdel-Mageed,Debasis Mondal

Oncology reports 36:1819-28 PubMed27572739

2016

PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN.

Applications

WB

Species

Human

Jianbo Xiong,Zhengrong Li,Yang Zhang,Daojiang Li,Guoyang Zhang,Xianshi Luo,Zhigang Jie,Yi Liu,Yi Cao,Zhibiao Le,Shengxing Tan,Wenyu Zou,Peitao Gong,Lingyu Qiu,Yuanyuan Li,Huan Wang,Heping Chen

Journal of translational medicine 14:71 PubMed26975394

2016

Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.

Applications

Unspecified application

Species

Unspecified reactive species

Esten N Vandsemb,Helena Bertilsson,Pegah Abdollahi,Øystein Størkersen,Thea Kristin Våtsveen,Morten Beck Rye,Torstein Baade Rø,Magne Børset,Tobias S Slørdahl
View all publications
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