Rabbit Polyclonal PTPIP51 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RMDN3 aa 150-350.
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Publications
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- Science advances 6:eaax90932020Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlessandro Rimessi et. al.PubMed 32494695
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human RMDN3 aa 150-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q96TC7
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Orangutan | Predicted | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Orangutan | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Orangutan | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Orangutan | Dilution info - | Notes - |
Target data
Function
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
Alternative names
FAM82A2, FAM82C, PTPIP51, hucep-10, UNQ3122/PRO10274, RMDN3, Regulator of microtubule dynamics protein 3, RMD-3, hRMD-3, Cerebral protein 10, Protein FAM82A2, Protein FAM82C, Protein tyrosine phosphatase-interacting protein 51, TCPTP-interacting protein 51
Recommended products
Rabbit Polyclonal PTPIP51 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RMDN3 aa 150-350.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human RMDN3 aa 150-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q96TC7
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PTPIP51 also known as Protein Tyrosine Phosphatase-Interacting Protein 51 functions at a mechanical level by interacting with protein tyrosine phosphatases and kinases which are key regulators of signal transduction. PTPIP51 has a molecular mass of approximately 51 kDa. The protein is expressed in various tissues including the brain testis and skeletal muscle. Its interactions suggest a role in maintaining cellular function and signaling.
- Biological function summary
The PTPIP51 protein plays a role in cellular processes such as apoptosis and cellular differentiation. It is believed to associate with other proteins to form complexes which influence mitochondrial function and cellular energy metabolism. Through these interactions PTPIP51 aids in maintaining cellular homeostasis and regulating cell survival mechanisms.
- Pathways
PTPIP51 participates in the regulation of the MAPK/ERK pathway and the insulin signaling pathway. It interacts with proteins such as RAF1 and GRB2 to convey signals from the cell surface to the DNA in the cell nucleus affecting cell division and proliferation. These pathways highlight the protein’s importance in controlling cellular growth and reaction to external stimuli.
- Associated diseases and disorders
PTPIP51 has connections to neurodegenerative disorders like Alzheimer's disease and metabolic conditions such as obesity. In Alzheimer’s alterations in PTPIP51 are linked with the dysregulation of mitochondrial function and it interacts with proteins such as Tau involved in neurofibrillary tangles. In obesity PTPIP51 is connected to insulin resistance engaging with protein partners like IRS1 to influence glucose uptake and metabolism.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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6 product images
Western blot - Anti-PTPIP51 antibody (ab224081)
All lanes: Western blot - Anti-PTPIP51 antibody (ab224081) at 1/250 dilution
All lanes: Caco-2 (human colorectal adenocarcinoma cell line) cell lysate
Predicted band size: 52 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPIP51 antibody (ab224081)
Paraffin-embedded human testis tissue staining PTPIP51 with ab224081 at 1/500 dilution in immunohistochemical analysis. Strong cytoplasmic positibity in seminiferous duct cells.
Immunocytochemistry/ Immunofluorescence - Anti-PTPIP51 antibody (ab224081)
PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for PTPIP51 (green) using ab224081 (4 μg/ml) in ICC/IF.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPIP51 antibody (ab224081)
Paraffin-embedded human skeletal muscle tissue staining PTPIP51 with ab224081 at 1/500 dilution in immunohistochemical analysis. Weak cytoplasmic positivity in myocytes.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPIP51 antibody (ab224081)
Paraffin-embedded human skin tissue staining PTPIP51 with ab224081 at 1/500 dilution in immunohistochemical analysis. Moderate to strong cytoplasmic positibity in keratinocytes.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPIP51 antibody (ab224081)
Paraffin embedded human testis tissue stained for PTPIP51 with ab224081 (1/1000 dilution) in immunohistochemical analysis.
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