JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB168479

Anti-PTPMT1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal PTPMT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PTPMT1.

View Alternative Names

MOSP, PLIP, PNAS-129, PTPMT1, Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, PTEN-like phosphatase, Phosphoinositide lipid phosphatase, Protein-tyrosine phosphatase mitochondrial 1

1 Images
Western blot - Anti-PTPMT1 antibody (AB168479)
  • WB

Unknown

Western blot - Anti-PTPMT1 antibody (AB168479)

All lanes:

Western blot - Anti-PTPMT1 antibody (ab168479) at 1 µg/mL

Lane 1:

PTPMT1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 23 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PTPMT1.

Q8WUK0

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPMT1 also known as protein tyrosine phosphatase mitochondrial 1 has a molecular mass of approximately 23 kDa. This protein is a unique phosphatase localized to the mitochondria. It specifically dephosphorylates phosphatidylinositol phosphates and plays a critical role in mitochondrial function. PTPMT1 is expressed highly in tissues with significant energy demands like the heart and skeletal muscle suggesting its role in energy metabolism.
Biological function summary

A phosphatase that is involved in important tasks within the mitochondria PTPMT1 contributes significantly to the regulation of mitochondrial metabolism. It removes phosphate groups from target substrates which is essential for the biosynthesis of cardiolipin an important lipid in mitochondrial membrane composition. Although not formally part of a large complex it interacts closely with other mitochondrial enzymes to maintain lipid homeostasis.

Pathways

Lipid metabolism and insulin signaling both involve PTPMT1. It mediates its actions through the biosynthesis of phosphatidylinositol derivatives that influence the insulin signaling pathway. It has a connection with the PI3K/Akt signaling cascade affecting the actions of proteins such as Akt and PDK1 which play integral roles in cellular energy balance and glucose homeostasis.

Improper PTPMT1 function relates closely to metabolic disorders particularly diabetes mellitus. PTPMT1 activity affects insulin signaling and its dysregulation contributes to insulin resistance. There is also an association with mitochondrial dysfunction which may lead to neurodegenerative disorders. In these contexts PTPMT1's interaction with proteins like insulin receptor substrate (IRS) can provide avenues to study therapeutic targets for related diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed : 24709986).
See full target information PTPMT1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica Polonica 69:417-422 PubMed35696596

2022

USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Meiqin Liu,Shile Gao,Xingjun Xu,Lijie Zhang,Bin Xu,Donghui Lu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB153987

Anti-LCLAT1 antibody

Western blot - Anti-LCLAT1 antibody (AB153987)

  • 0
  • 0
Proteins & Peptides

AB116204

Recombinant Human PTPMT1 protein

SDS-PAGE - Recombinant Human PTPMT1 protein (AB116204)

  • 0
  • 0
Primary Antibodies

AB273052

Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free (AB273052)

  • 0
  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com