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AB198882

Anti-PTPN13/FAP-1 antibody

0

(1 Review)

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(3 Publications)

Rabbit Polyclonal PTPN13/FAP-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PTPN13.

View Alternative Names

PNP1, PTP1E, PTPL1, PTPN13, Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, PTP-BAS, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase PTPL1, FAP-1, PTP-E1, hPTPE1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN13/FAP-1 antibody (AB198882)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN13/FAP-1 antibody (AB198882)

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling PTPN13/FAP-1 with ab198882 at 1/30 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN13/FAP-1 antibody (AB198882)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN13/FAP-1 antibody (AB198882)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling PTPN13/FAP-1 with ab198882 at 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PTPN13. The exact immunogen used to generate this antibody is proprietary information.

Q12923

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPN13 also known as FAP-1 or Fas-associated phosphatase-1 is a non-receptor type protein tyrosine phosphatase with a reported molecular weight of approximately 270 kDa. This enzyme contains several PDZ domains contributing to its interactions with other proteins. PTPN13 is expressed in various tissues including the brain liver and heart indicating its wide-ranging roles in cellular functions.
Biological function summary

PTPN13 plays a critical role in the regulation of apoptosis and cell-cell adhesion. It interacts with components of the cytoskeleton and other signaling proteins functioning as part of protein complexes involved in maintaining cellular structure and signaling. By dephosphorylating specific phosphotyrosine residues PTPN13 controls signaling pathways that determine cell survival and communication.

Pathways

PTPN13 is involved in pathways such as the Fas-mediated apoptosis signaling and insulin signaling pathways. It interacts with proteins like the Fas receptor and IRS1 within these pathways modulating signals that control apoptosis and metabolic responses. PTPN13's activity can affect downstream signaling events influencing cellular outcomes like survival or death in response to external stimuli.

Researchers have linked PTPN13 with cancer and insulin resistance. The protein's interaction with Fas-associated proteins suggests a role in tumorigenesis particularly related to apoptosis evasion. In the context of metabolic disorders PTPN13's function in the insulin signaling pathway connects it to insulin resistance where its regulation of IRS1 affects insulin response. These associations highlight the potential of targeting PTPN13 in therapeutic strategies for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed : 15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed : 23604317).
See full target information PTPN13
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 11:7603-7612 PubMed30464509

2018

Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting IκBα.

Applications

Unspecified application

Species

Unspecified reactive species

Yacheng Wang,Miao Li,Ting Huang,Jun Li

Oncotarget 9:25891-25902 PubMed29899829

2018

Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.

Applications

Unspecified application

Species

Unspecified reactive species

Weiqi Huang,Ling Bei,Elizabeth A Eklund

Journal of cellular and molecular medicine 21:2852-2862 PubMed28653805

2017

MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhuang,Tao Shou,Ke Li,Chun-Lin Gao,Lin-Can Duan,Li-Zhou Fang,Qin-Yong Zhang,Zong-Ning Chen,Chao Zhang,Shou-Tao Yang,Gao-Feng Li
View all publications
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Product promise

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