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AB230300

Anti-PTPN18 antibody

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(2 Publications)

Rabbit Polyclonal PTPN18 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPN18 aa 1-250.

View Alternative Names

BDP1, PTPN18, Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN18 antibody (AB230300)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPN18 antibody (AB230300)

Paraffin-embedded human brain tissue stained for PTPN18 with ab230300 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-PTPN18 antibody (AB230300)
  • WB

Supplier Data

Western blot - Anti-PTPN18 antibody (AB230300)

All lanes:

Western blot - Anti-PTPN18 antibody (ab230300) at 1/1000 dilution

All lanes:

Rat heart tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 50 kDa

Observed band size: 50 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTPN18 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q99952

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPN18 also known as protein tyrosine phosphatase non-receptor type 18 or BDP1 functions as a tyrosine phosphatase enzyme involved in signaling pathways by removing phosphate groups from tyrosine residues on proteins. This protein has a molecular mass of approximately 48 kDa. It is expressed in various tissues with particular presence in the brain liver and skeletal muscle. By modulating phosphorylation states PTPN18 plays a vital role in cellular signal transduction.
Biological function summary

PTPN18 influences cellular processes such as growth differentiation and apoptosis by regulating phosphorylation events. This enzyme acts in concert with other signaling molecules although it does not form specific complexes itself. PTPN18 interacts with substrates like the HER2/ERBB2 receptor impacting critical pathways regulating cell proliferation and survival. These interactions allow PTPN18 to exert control over cellular responses helping maintain homeostasis within biological systems.

Pathways

PTPN18 is an important modulator within the ERK/MAPK and PI3K/Akt signaling cascades. Within the ERK/MAPK pathway PTPN18 interacts with proteins such as SHC1 and GRB2 to help regulate cellular activities like division and differentiation. In the PI3K/Akt pathway PTPN18 affects cell survival and metabolism by regulating components in the signaling cascade. These interactions establish PTPN18 as a critical player in transmitting extracellular signals to the intracellular machinery.

PTPN18 has connections to cancer and metabolic disorders. It is implicated in the progression and prognosis of certain cancers including breast cancer where it modulates the activity of the ERBB2 receptor. By influencing phosphorylation PTPN18 can impact tumor growth and response to treatment. Additionally alterations in PTPN18 activity may contribute to metabolic diseases through its effects on receptor signaling and cellular metabolism. Understanding these interactions highlights PTPN18's relevance in disease mechanisms and the potential for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
See full target information PTPN18
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell & bioscience 14:88 PubMed38956702

2024

NOX4-mediated astrocyte ferroptosis in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yasenjiang Maimaiti,Ting Su,Zhanying Zhang,Lingling Ma,Yuan Zhang,Hong Xu

Histology and histopathology 40:215-223 PubMed38855855

2024

Mechanism of PTPN18 for regulating the migration and invasion of endometrial cancer cells via the MYC/PI3K/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shiqi Suo,Song Chen,Liyuan Zhou,Ruili Xu,Jingxia Li,Wei Li
View all publications
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