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AB233806

Anti-PTPRD antibody [5H5D7]

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(4 Publications)

Mouse Monoclonal PTPRD antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050-1300.

View Alternative Names

Receptor-type tyrosine-protein phosphatase delta, Protein-tyrosine phosphatase delta, R-PTP-delta, PTPRD

3 Images
Flow Cytometry - Anti-PTPRD antibody [5H5D7] (AB233806)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-PTPRD antibody [5H5D7] (AB233806)

Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling PTPRD using ab233806 at 1/200 dilution (green) and a negative control (red).

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)
  • WB

Supplier Data

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

Expected MW is 47.4 kDa.

All lanes:

Western blot - Anti-PTPRD antibody [5H5D7] (ab233806) at 1/500 dilution

All lanes:

Human PTPRD (AA: extra 1077-1265) recombinant protein.

Predicted band size: 215 kDa

false

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)
  • WB

Supplier Data

Western blot - Anti-PTPRD antibody [5H5D7] (AB233806)

All lanes:

Western blot - Anti-PTPRD antibody [5H5D7] (ab233806) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate.

Lane 2:

PTPRD (AA: extra 1077-1265)-hIgGFc transfected HEK-293 cell lysate.

Predicted band size: 215 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

5H5D7

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050-1300. The exact immunogen used to generate this antibody is proprietary information.

P23468

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPRD also called Protein Tyrosine Phosphatase Receptor Type D functions as a receptor-type protein tyrosine phosphatase. It is an enzyme that removes phosphate groups from tyrosine residues in proteins. This protein has a mass of about 215 kDa and consists of extracellular transmembrane and intracellular regions. It is expressed broadly in human tissues notably in the nervous system and is present in neurons.
Biological function summary

This protein plays a significant role in cell adhesion and signal transduction. It is important for neuronal development as it helps form synaptic connections influencing the communication between neurons. PTPRD forms part of the protein complex involved in cellular signaling pathways regulating processes such as axon guidance and neural patterning. The extracellular regions which interact with cell surface proteins aid in these functions.

Pathways

PTPRD engages in neurodevelopmental and synaptic signaling pathways. It interacts with proteins like LAR (Leukocyte antigen-related) and N-cadherin both involved in neural development. PTPRD’s phosphatase activity alters the phosphorylation status of downstream components integrating into pathways that are critical for neural network formation and function.

PTPRD has been linked to cancer and neurological disorders such as autism spectrum disorder (ASD). Genetic studies have identified that disruptions in the PTPRD gene are associated with increased cancer risk possibly due to its role in cell growth regulation. In neurological contexts PTPRD effects on synaptic connections suggest a connection with ASD where dysfunctions in neural connectivity are common. It shares a pathway relationship with proteins like contactin and TAG-1 which are also implicated in neural development anomalies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.
See full target information Receptor-type tyrosine-protein phosphatase delta
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 82:2779-2796.e10 PubMed35675814

2022

AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.

Applications

Unspecified application

Species

Unspecified reactive species

Hana Cho,Elizabeth T Abshire,Maximilian W Popp,Christoph Pröschel,Joshua L Schwartz,Gene W Yeo,Lynne E Maquat

Nature communications 12:1848 PubMed33758193

2021

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoyuki Yoshida,Atsushi Yamagata,Ayako Imai,Juhyon Kim,Hironori Izumi,Shogo Nakashima,Tomoko Shiroshima,Asami Maeda,Shiho Iwasawa-Okamoto,Kenji Azechi,Fumina Osaka,Takashi Saitoh,Katsumi Maenaka,Takashi Shimada,Yuko Fukata,Masaki Fukata,Jumpei Matsumoto,Hisao Nishijo,Keizo Takao,Shinji Tanaka,Shigeo Okabe,Katsuhiko Tabuchi,Takeshi Uemura,Masayoshi Mishina,Hisashi Mori,Shuya Fukai

International journal of clinical and experimental pathology 12:4222-4231 PubMed31933822

2019

miR-516a-3p promotes proliferation, migration, and invasion and inhibits apoptosis in lung adenocarcinoma by targeting PTPRD.

Applications

Unspecified application

Species

Unspecified reactive species

Anhao Wu,Xin Yang,Bing Zhang,Shuting Wang,Gaofeng Li

Kidney international 81:458-68 PubMed22166849

2011

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Leyi Gu,Xinyue Liang,Lihua Wang,Yucheng Yan,Zhaohui Ni,Huili Dai,Jiayuan Gao,Shan Mou,Qin Wang,Xinyu Chen,Liming Wang,Jiaqi Qian
View all publications
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