AB111207

Anti-PTPRM antibody

Name: Anti-PTPRM antibody (ab111207) | Abcam
Brand: Abcam Limited
SKU: AB111207
Price: 565 USD
Availability: InStock

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(1 Publication)

Goat Polyclonal PTPRM antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PTPRM aa 1350-1400.

View Alternative Names

PTPRL1, PTPRM, Receptor-type tyrosine-protein phosphatase mu, Protein-tyrosine phosphatase mu, R-PTP-mu

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

ab111207, at 3.75 μg/ml dilution, staining PTPRM in formalin-fixed, paraffin-embedded Human thyroid tissue by Immunohistochemistry.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

ab111207, at 3.75 μg/ml dilution, staining PTPRM in formalin-fixed, paraffin-embedded Human uterus tissue by Immunohistochemistry.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PTPRM aa 1350-1400. The exact immunogen used to generate this antibody is proprietary information.

P28827

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPRM also known as Protein Tyrosine Phosphatase Receptor Type M or RPTPmu is a transmembrane protein that acts mechanically by dephosphorylating tyrosine residues on target proteins. This protein weighs approximately 155 kDa. PTPRM displays expression mainly in the brain and epithelial tissues. It is comprised of an extracellular segment a transmembrane domain and an intracellular segment with catalytic activity. Its role involves facilitating cell-cell adhesion through homophilic interactions significantly impacting signaling events that regulate cellular processes.

Biological function summary

Within the human cells PTPRM plays a vital role in controlling cell adhesion migration and signaling. As part of the leukocyte common antigen-related (LAR) phosphatase family this protein collaborates with other proteins to modulate cellular junction integrity and movement. The extracellular domain of PTPRM participates in cellular communication while its intracellular catalytic property dephosphorylates signaling molecules to fine-tune cellular responses. These activities highlight its importance in maintaining tissue organization and signaling networks.

Pathways

PTPRM is involved in the regulation of the cadherin signaling pathway and MAPK signaling pathway. Through its interactions it modulates E-cadherin-mediated adhesion complexes where it cooperates closely with proteins like β-catenin to regulate adhesion strength and cell position. Additionally PTPRM influences the MAPK signaling cascade affecting cell proliferation and differentiation processes. By fine-tuning these pathways PTPRM plays a significant role in ensuring normal cellular function and communication.

Mutations or dysregulations in PTPRM can be associated with cancer particularly colorectal carcinoma and neurological disorders like epilepsy. In colorectal cancer PTPRM's interaction with E-cadherin is particularly affected influencing tumor growth and metastasis. In neurological pathways PTPRM's regulation of signaling proteins like SRC can play significant roles. Alterations in these pathways may lead to abnormal neuronal signaling implicated in epilepsy highlighting the importance of PTPRM in maintaining healthy cellular function and preventing disease.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed : 10753936, PubMed : 17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed : 21998202).

See full target information PTPRM

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Endocrine connections 8:1126-1135 PubMed31349215

2019

PTPRM, a candidate tumor suppressor gene in small intestinal neuroendocrine tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Elham Barazeghi,Per Hellman,Gunnar Westin,Peter Stålberg

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PTPRM antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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