JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB231607

Anti-PTPRM antibody

Be the first to review this product! Submit a review

|

(2 Publications )

Rabbit Polyclonal PTPRM antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTPRM aa 1150 to C-terminus.

View Alternative Names

PTPRL1, PTPRM, Receptor-type tyrosine-protein phosphatase mu, Protein-tyrosine phosphatase mu, R-PTP-mu

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB231607)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB231607)

Formalin-fixed, paraffin-embedded human kidney tissue stained for PTPRM using ab231607 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-PTPRM antibody (AB231607)
  • WB

Supplier Data

Western blot - Anti-PTPRM antibody (AB231607)

All lanes:

Western blot - Anti-PTPRM antibody (ab231607) at 2 µg/mL

All lanes:

Recombinant human PTPRM protein

Predicted band size: 164 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PTPRM aa 1150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P28827

style
left-column

Alternative Products

Primary Antibodies

AB233815

Anti-PTPRM antibody [1H6D10]

Western blot - Anti-PTPRM antibody [1H6D10] (AB233815)

  • 0
  • 0
Primary Antibodies

AB111207

Anti-PTPRM antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTPRM antibody (AB111207)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB302698

Alexa Fluor® 647 Anti-CD14 antibody [SP192]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD14 antibody [SP192] (AB302698)

  • 0
  • 0
Primary Antibodies

AB281583

Anti-CD31 antibody [RM1006]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [RM1006] (AB281583)

  • 5
  • 5
Primary Antibodies

AB125208

Anti-COL4A2 antibody

Western blot - Anti-COL4A2 antibody (AB125208)

  • 0
  • 0
Primary Antibodies

AB2900

Anti-EEA1 antibody - Early Endosome Marker

KO Validated|Lab Essentials

Western blot - Anti-EEA1 antibody - Early Endosome Marker (AB2900)

  • 4
  • 39
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231607 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTPRM also known as Protein Tyrosine Phosphatase Receptor Type M or RPTPmu is a transmembrane protein that acts mechanically by dephosphorylating tyrosine residues on target proteins. This protein weighs approximately 155 kDa. PTPRM displays expression mainly in the brain and epithelial tissues. It is comprised of an extracellular segment a transmembrane domain and an intracellular segment with catalytic activity. Its role involves facilitating cell-cell adhesion through homophilic interactions significantly impacting signaling events that regulate cellular processes.
Biological function summary

Within the human cells PTPRM plays a vital role in controlling cell adhesion migration and signaling. As part of the leukocyte common antigen-related (LAR) phosphatase family this protein collaborates with other proteins to modulate cellular junction integrity and movement. The extracellular domain of PTPRM participates in cellular communication while its intracellular catalytic property dephosphorylates signaling molecules to fine-tune cellular responses. These activities highlight its importance in maintaining tissue organization and signaling networks.

Pathways

PTPRM is involved in the regulation of the cadherin signaling pathway and MAPK signaling pathway. Through its interactions it modulates E-cadherin-mediated adhesion complexes where it cooperates closely with proteins like β-catenin to regulate adhesion strength and cell position. Additionally PTPRM influences the MAPK signaling cascade affecting cell proliferation and differentiation processes. By fine-tuning these pathways PTPRM plays a significant role in ensuring normal cellular function and communication.

Mutations or dysregulations in PTPRM can be associated with cancer particularly colorectal carcinoma and neurological disorders like epilepsy. In colorectal cancer PTPRM's interaction with E-cadherin is particularly affected influencing tumor growth and metastasis. In neurological pathways PTPRM's regulation of signaling proteins like SRC can play significant roles. Alterations in these pathways may lead to abnormal neuronal signaling implicated in epilepsy highlighting the importance of PTPRM in maintaining healthy cellular function and preventing disease.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed : 10753936, PubMed : 17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed : 21998202).
See full target information PTPRM
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 14: PubMed35884490

2022

Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zeinab Kosibaty,Odd Terje Brustugun,Inger Johanne Zwicky Eide,Georgios Tsakonas,Oscar Grundberg,Luigi De Petris,Marc McGowan,Per Hydbring,Simon Ekman

The Journal of physiology 598:5427-5451 PubMed32893883

2020

Functional, proteomic and bioinformatic analyses of Nrf2- and Keap1- null skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Lie Gao,Vikas Kumar,Neetha Nanoth Vellichirammal,Song-Young Park,Tara L Rudebush,Li Yu,Won-Mok Son,Elizabeth J Pekas,Ahmed M Wafi,Juan Hong,Peng Xiao,Chittibabu Guda,Han-Jun Wang,Harold D Schultz,Irving H Zucker
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com