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AB128040

Anti-PTTG1IP antibody

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(6 Publications)

Rabbit Polyclonal PTTG1IP antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PTTG1IP.

View Alternative Names

C21orf1, C21orf3, PTTG1IP, Pituitary tumor-transforming gene 1 protein-interacting protein, Pituitary tumor-transforming gene protein-binding factor, PBF, PTTG-binding factor

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTTG1IP antibody (AB128040)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTTG1IP antibody (AB128040)

ab128040, at a concentration of 5 µg/ml, staining PTTG1IP in paraffin-embedded Human Prostate, Epithelium tissue by Immunohistochemistry.

Western blot - Anti-PTTG1IP antibody (AB128040)
  • WB

Unknown

Western blot - Anti-PTTG1IP antibody (AB128040)

All lanes:

Western blot - Anti-PTTG1IP antibody (ab128040) at 1/500 dilution

Lane 1:

RAW264.7 cell extract

Lane 2:

RAW264.7 cell extract with synthesized peptide

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human PTTG1IP. The exact immunogen used to generate this antibody is proprietary information.

P53801

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PTTG1IP also known as PTTG1 interacting protein plays an important role in cell regulation by facilitating the transport of the securin protein PTTG1 to the cell nucleus. This protein has a molecular weight of approximately 23 kDa. It is expressed highly in the testis but also found in other tissues like the placenta and thymus. The transport function of PTTG1IP ensures proper cell division and control of genomic stability.
Biological function summary

PTTG1IP is essential in controlling the cell cycle by enabling the proper localization of the PTTG1 protein. By being a part of the larger regulatory network PTTG1IP impacts the balance between cell proliferation and apoptosis. It is not a part of a classical protein complex but interacts directly with its namesake PTTG1 to carry out its functions. This interaction underpins critical cellular processes necessary for tissue growth and repair.

Pathways

PTTG1IP functions in the regulation of the cell cycle and plays a role in the mitotic spindle checkpoint. It interacts closely with proteins such as Cyclin B1 and separase which are central to these pathways. By modulating the activity of PTTG1 PTTG1IP helps to ensure proper chromosomal segregation during mitosis maintaining genomic integrity across cell generations.

Alterations in PTTG1IP expression are linked to cancer particularly breast cancer and pituitary tumors. The overexpression of PTTG1IP corresponds with increased levels of PTTG1 which can disrupt normal cellular controls and promote oncogenic processes. In this context PTTG1IP may influence the stability of other proteins like securin and p53 which are integral in tumorigenic pathways highlighting its significance in cancer biology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May facilitate PTTG1 nuclear translocation.
See full target information PTTG1IP
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology, immunotherapy : CII 73:69 PubMed38430268

2024

Construction of an immune predictive model and identification of TRIP6 as a prognostic marker and therapeutic target of CRC by integration of single-cell and bulk RNA-seq data.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Xitu Luo,Zilang Zhang,Yepeng Chen,Yongliang Dai,Jianzhong Deng,Chengyu Yang,Hao Liu

Cancer cell international 22:411 PubMed36527013

2022

Cell senescence-associated genes predict the malignant characteristics of glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chenyang Tan,Yan Wei,Xuan Ding,Chao Han,Zhongzheng Sun,Chengwei Wang

Annals of medicine 54:211-226 PubMed35037540

2022

Identification of prognostic biomarkers in papillary renal cell carcinoma and PTTG1 may serve as a biomarker for predicting immunotherapy response.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Tian,Wen-Hao Xu,Fu-Jiang Xu,Hui Li,Aihetaimujiang Anwaier,Hong-Kai Wang,Fang-Ning Wan,Yu- Zhu,Da-Long Cao,Yi-Ping Zhu,Guo-Hai Shi,Yuan-Yuan Qu,Hai-Liang Zhang,Ding-Wei Ye

Molecular therapy. Nucleic acids 22:1078-1091 PubMed33294294

2020

Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Kunpeng Wang,Feng Li,Yuan Yuan,Liang Shan,Yong Cui,Jing Qu,Feng Lian

Journal of cellular biochemistry 120:9964-9978 PubMed30582202

2018

MicroRNA-329-mediated PTTG1 downregulation inactivates the MAPK signaling pathway to suppress cell proliferation and tumor growth in cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi-Gao Hu,Chao-Wen Zheng,Hui-Zhao Su,Yong-Lian Zeng,Cheng-Jie Lin,Zhen-Ya Guo,Fu-Di Zhong,Guan-Dou Yuan,Song-Qing He

BMC cancer 17:705 PubMed29078751

2017

PTTG1-interacting protein (PTTG1IP/PBF) predicts breast cancer survival.

Applications

Unspecified application

Species

Unspecified reactive species

Heli Repo,Natalia Gurvits,Eliisa Löyttyniemi,Marjukka Nykänen,Minnamaija Lintunen,Henna Karra,Samu Kurki,Teijo Kuopio,Kati Talvinen,Mirva Söderström,Pauliina Kronqvist
View all publications
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Product promise

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