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AB279364

Anti-PVRL1/NECTIN1 antibody [OTI6F8]

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(1 Publication)

Mouse Monoclonal PVRL1/NECTIN1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NECTIN1.

View Alternative Names

CD111, HVEC, PRR1, PVRL1, NECTIN1, Nectin-1, Herpes virus entry mediator C, Herpesvirus Ig-like receptor, Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1, Herpesvirus entry mediator C, HveC, HIgR

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PVRL1/NECTIN1 antibody [OTI6F8] (AB279364)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PVRL1/NECTIN1 antibody [OTI6F8] (AB279364)

Paraffin embedded carcinoma of human bladder tissue stained for PVRL1 using ab279364 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10 minutes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PVRL1/NECTIN1 antibody [OTI6F8] (AB279364)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PVRL1/NECTIN1 antibody [OTI6F8] (AB279364)

Paraffin embedded adenocarcinoma of human ovary tissue stained for PVRL1 using ab279364 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI6F8

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NECTIN1.

Q15223

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PVRL1 also known as NECTIN1 or nectin-1 functions mechanically as an immunoglobulin-like cell adhesion molecule. It plays a role in creating adherens junctions between cells operating as both a homophilic and heterophilic binding partner. Nectin-1 has a molecular mass of approximately 97 kDa. It is expressed prominently in epithelial tissues and particularly in the nervous system which suggests it plays an important role in cell-cell communication in these areas.
Biological function summary

Nectin-1 facilitates cellular processes through its involvement in cell adhesion complexes. It functions as part of a larger complex including proteins like afadin which links to the actin cytoskeleton and promotes cell junction integrity. This organization impacts cellular adhesion migration and proliferation. Nectin-1's adhesive functions are fundamental in maintaining structural tissues and transmitting signals within cells a necessity for development and tissue maintenance.

Pathways

Nectin-1 contributes to the activation of the MAPK/ERK signaling pathway central to regulating various cell functions including proliferation and differentiation. It also participates in the cadherin-catenin complex pathway working in conjunction with E-cadherin a critical protein in maintaining epithelial cell layer integrity. These pathways highlight nectin-1’s role as a signal transducer affecting how cells interact and react to their environment.

Nectin-1 is implicated in cleft lip and palate disorder. Mutations affecting nectin-1 can disrupt cell adhesion processes necessary for proper development of facial structures. Furthermore alterations in nectin-1 gene expression are associated with susceptibility to herpes simplex virus infections as nectin-1 acts as a viral entry receptor. In these conditions its interaction with closely related membrane proteins such as nectin-3 is significant in disease manifestation and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed : 21325282). Acts by forming homophilic or heterophilic trans-dimers (PubMed : 21325282). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth-promoting activity (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3 : NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity).. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV (PubMed : 21980294, PubMed : 25231300, PubMed : 28381567, PubMed : 28542478, PubMed : 34587223, PubMed : 38857290, PubMed : 39048823, PubMed : 39048830, PubMed : 7721102, PubMed : 9616127, PubMed : 9657005). Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells (PubMed : 34587223).
See full target information NECTIN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of pineal research 76:e70002 PubMed39539049

2024

Melatonin Protects Against Cocaine-Induced Blood-Brain Barrier Dysfunction and Cognitive Impairment by Regulating miR-320a-Dependent GLUT1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Yi Wei,Hui Liu,Yuan Li,Dan Zhao,Bo Wang,Hui-Jie Wang,Li Wang,Kang-Ji Wang,Jin-Li Yue,Hong-Yan Zhang,Tian-Yue Li,Yi-Jue Miao,Kai-Li Wang,Pai-Ge Tong,Zhuo Zhang,Ze-Ye Li,Zheng Shi,Jia-Yuan Yao,Dong-Xin Liu,Wen-Gang Fang,Bo Li,De-Shu Shang,Yuan Lyu,Hong-Zan Sun,Wei-Dong Zhao,Yu-Hua Chen
View all publications
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