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AB110052

Anti-PWWP domain-containing protein 2B antibody

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(1 Publication)

Rabbit Polyclonal PWWP domain-containing protein 2B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PWWP2B.

View Alternative Names

PWWP2, PWWP2B, PWWP domain-containing protein 2B

1 Images
Western blot - Anti-PWWP domain-containing protein 2B antibody (AB110052)
  • WB

Unknown

Western blot - Anti-PWWP domain-containing protein 2B antibody (AB110052)

All lanes:

Western blot - Anti-PWWP domain-containing protein 2B antibody (ab110052) at 1/500 dilution

Lane 1:

LOVO cell extract at 30 µg

Lane 2:

LOVO cell extract at 30 µg with immunising peptide

Predicted band size: 64 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PWWP2B. The exact immunogen used to generate this antibody is proprietary information.

Q6NUJ5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PWWP domain-containing protein 2B also known as PWWP2B is a protein that has a significant role in chromatin binding and remodeling. This protein having a molecular mass of approximately 62 kDa contains a PWWP domain which enables the recognition of methylated histone marks. PWWP2B is expressed in various tissues with a strong presence in the nucleus where it functions closely with chromatin. The protein is involved in regulating the accessibility of DNA to transcription factors influencing gene expression.
Biological function summary

PWWP2B interacts with chromatin to facilitate transcriptional regulation. It is known to form part of larger protein complexes that include chromatin remodelers and transcription factors contributing to the dynamic restructuring of chromatin. The ability of PWWP2B to bind methylated histones suggests a role in histone modification processes and subsequent gene expression control. These interactions imply a primary function in modulating the accessibility of chromatin for gene transcription.

Pathways

PWWP2B operates within the chromatin organization and transcriptional regulation pathways. It works hand in hand with other proteins like Methyl-CpG-binding protein 2 (MeCP2) which is involved in transcription regulation that impacts neural development. Additionally PWWP2B's interaction with other chromatin remodelers helps orchestrate the fine-tuning of transcriptional activity emphasizing its role in gene expression pathways.

PWWP2B has links to cancer and neurodevelopmental disorders. Alterations or dysregulations of PWWP2B expression can lead to aberrant patterns of chromatin accessibility which may contribute to oncogenesis. Furthermore the protein's relation to MeCP2 indicates a potential role in disorders like Rett syndrome where gene expression modulation is a critical aspect. These connections make PWWP2B an interesting target for research into therapeutic interventions for related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed : 30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed : 30228260). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (By similarity). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (By similarity).
See full target information PWWP2B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:43846 PubMed28266613

2017

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yousuf O Ali,Gillian Bradley,Hui-Chen Lu
View all publications
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