Anti-PXK antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PXK also known as Phosphoinositide-binding protein FAM20-kinase or MOYBG Protein Kinase-like is a membrane-associated protein with a molecular mass of approximately 59 kDa. Experts have identified it for its kinase-like properties although it lacks conventional kinase activity. PXK is expressed in various tissues including brain liver and kidney with significant presence in neuronal cells. Its mechanical role involves modulating neuronal signaling and membrane dynamics through interactions with phosphoinositides.

Biological function summary

PXK participates in the regulation of cellular organization and synaptic functions. While not a direct component of signaling complexes it influences processes related to cytoskeletal rearrangement and membrane trafficking. Through its phosphoinositide-binding domains PXK impacts the localization and assembly of proteins involved in synaptic vesicle turnover. As a scaffolding protein it indirectly affects signal transduction pathways by altering the spatial arrangement of interacting proteins.

Pathways

PXK influences the phosphoinositide signaling pathway and the synaptic vesicle cycle. Its interactions with proteins like dynamin and synaptojanin allow researchers to deduce its role in vesicle endocytosis and membrane recycling. PXK indirectly modulates the activity of these proteins impacting the efficiency of synaptic transmission. These pathways underline its role in maintaining synaptic stability and plasticity essential for proper neuronal communication.

Associated diseases and disorders

Researchers have linked PXK to neurodegenerative diseases and certain immune disorders. Alterations in PXK expression have association with conditions such as Alzheimer’s disease where disrupted synaptic function is an important feature. Furthermore its interaction with immune-related proteins like NF-κB suggests a role in autoimmune processes. These links highlight the importance of PXK in maintaining cellular function and its potential as a therapeutic target in related diseases.